The focus of the research group is the investigation of the molecular mechanism underlining the development of different neurodegenerative disorder, known as NBIA disorders, which share the feature of extensive brain iron accumulation. By the use of cellular and animal models (zebrafish) the group studies the basic biological role of the genes found to be mutated in selected NBIA subtype and investigate the effects of the mutation on iron homeostasis, mitochondria and other organelle functionality, lipid homeostasis. Both cellular and animal models are relevant starting point to develop potential therapeutic strategies.
Address:
Facoltà di Medicina e Chirurgia
Laboratori di Biologia Molecolare, Corpo A 2 Piano
Viale Europa 11
25123 Brescia
date/time interval:
(November 1, 2012 - )