Person
BARBON ALESSANDRO
Docenti di ruolo di Ia fascia
Course Catalogue:
I’m Full Professor of Cellular and Applied Biology at the Department of Molecular and Translational Medicine, Brescia University. I work in the field of Neurobiology with a particular interest in RNA biology. I’m one of the few Italian experts of “RNA editing”, a particular post transcriptional regulation that leads to modification of the information that is encoded in the DNA, thus increasing gene expression complexity. My research interests focus on: 1) revealing the correlations among RNA editing dysregulation, neurological disorders and their pharmacological medications; 2) uncovering the molecular correlations among post-transcriptional mechanism such as RNA editing, RNA splicing and RNA trafficking; 3) studying the biological and molecular mechanisms regulating the activity of the glutamatergic system.
Communications
Curriculum Vitae
Prof. Alessandro Barbon
FULL WORK ADDRESS: Division of Biology and Genetics, Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.
E-MAIL alessandro.barbon@unibs.it
CURRENT POSITION: Full Professor in Applied Biology, Dept. of Molecular and Translational Medicine, University of Brescia
WORK EXPERIENCE:
2021 - now Full Professor in Applied Biology, Dept. of Molecular and Translational Medicine, University of Brescia
2015 – 2021 Associate Professor, Dept. of Molecular and Translational Medicine, University of Brescia
2018 National Scientific Qualification as Full Professor in Applied Biology
2011 - now Group leader of the RNA biology Lab, Dept. of Molecular and Translational Medicine, University of Brescia.
2018 – now Member of the Central Board for the supervision of the Quality of the University of Brescia
2007 – 2012 Member of the Central Research Committee of the University of Brescia
2004 - 2015 Assistant Professor, Dept. of Molecular and Translational Medicine, University of Brescia
2002 - 2003 Postdoctoral Fellow, Dept. of Molecular and Translational Medicine, University of Brescia
EDUCATION AND TRAINING
November 2002: Ph.D in Molecular Genetics applied to Medical Science, University of Brescia
November 1999: Qualifying examination (Esame di Stato all'abilitazione della professione di Biologo)
March 1999: Awarded a four year Ph.D. grant Molecular Genetics applied to Medical Science at Department of Molecular and Translational Medicine, University of Brescia,
September 1998-March 1999: professional training in the Human Genetic lab at the University of Padova
July 1998: University degree in Biology Science cum laude (110/110 e lode), at the University of Padova
July 1993: High School Diploma (diploma di maturità scientifica) with 58 points out of 60
SCIENTIFIC MEMBERSHIPS
2003-now: Member of the Italian Society of Biology and Genetics (AIBG)
2017 - now: Member of the RNA Society
2021-now: Member of the Italian Society of Neuroscience (SINS)
GRANTS
HEAL ITALIA PNRR M4C2 2025-2026 (partecipant): Development of an ORGANoid-Based Platform for CAR-T Validation Using Nanoparticles Mediated mRNA Delivery
Cariplo foundation Grant 2017 (Principal Investigator of Operative Unit): MicroRNAs in Frailty-Associated Cognitive Impairment.
Health and Wealth 2015 projects by University of Brescia (component of Operative Unit; PI of working package): REFrACT – Analysis of the neurobiological mechanisms underlining treatment resistance to psychotropic drugs in innovative cellular models.
PRIN2015 (Principal Investigator of Operative Unit): Risposte maladattative dello stress: studio dei meccanismi che le regolano per identificare nuovi bersagli terapeutici nelle malattie neuropsichiatriche
Progetti Fondazione Banca del Monte di Lombardia-2014 (Co-Principal Investigator): Nuovi target molecolari per la terapia delle discinesie da L-DOPA in modelli animali di malattia di Parkinson: ruolo dei processi di RNA editing dei recettori AMPA
PRIN2012 (Principal Investigator of Operative Unit): Ketamine as a tool to understand the nature of rapid antidepressant action. Relevance for therapy of treatment-resistant depression
PRIN2009 (Principal Investigator of Operative Unit): La sinapsi stressata: Effetti sinaptici dello stress comportamentale e azione degli antidepressivi
2011-Lombardia regional grant (component of Operative Unit; PI of working package): NEDD- Network Enabled drug design
PRIN2007-(component of Operative Unit; PI of working package): Disturbi d’ansia e legati allo stress: nuovi meccanismi e bersagli farmacologici.
2007 – Grant from Ministry of Health (component of Operative Unit, PI of working package): Innovative strategies for depression treatment: novel pharmacological targets and preclinical studies for the personalization of therapy.
PRIN2005- (component of Operative Unit, PI of working package):
PRIN2003- (component of Operative Unit; PI of working package): Meccanismi di Neuroplasticità glutammatergica come bersagli molecolari per lo sviluppo di strategie farmacologiche innovative nei disturbi affettivi :approfondimento dei meccaismi e identificazione di potenziali
PRIN2001- (component of Operative Unit; PI of working package): Meccanismi di Neuroplasticità glutammatergica come bersagli molecolari per lo sviluppo di strategie farmacologiche innovative nei disturbi affettivi.
PUBLICATIONS
70 scientific articles indexed in Pubmed
H-index: 27 Citations: 1630 (source Scopus)
Total Impact Factor > 250
Scopus link: https://www.scopus.com/authid/detail.uri?authorId=6602866116
RESERCH INTEREST:
1) revealing the correlations among RNA metabolism dysregulation, neurological disorders and their pharmacological medications. 2) Uncovering the molecular correlations among post-transcriptional mechanisms. 3) Understanding the biological and molecular mechanisms regulating the activity of the glutamatergic and neutrophic systems in physiological and stress related conditions.
PRESENTATIONS IN NATIONAL/INTERNATIONAL CONGRESSES OR ORGANIZATION OF SCIENTIFIC CONGRESSES
• RNA Metabolism in neurodegenerative diseases, Pavia 27-28 giugno 2019; Barbon A: RNA editing in neurological diseases
• XX Congresso nazionale SIGU Napoli 17-18/11/2017; Barbon A. Glutamate receptor RNA editing in health and disease.
• XVI Congresso Nazionale AIBG Napoli, 26-27/9/2014; Barbon A: Modulation of dendritic AMPA receptor mRNA trafficking by RNA splicing and editing
• XII Congresso AIBG Trento 8-9/10/2010; Barbon A: Acute spinal cord injury persistently reduces R/G RNA editing of AMPA glutamate receptors
• Congresso Spine and Spinal cord 4 luglio 2008; Barbon A: Espressione e RNA editing dei recettori per il glutammato nel midollo spinale
• 7° Convegno FISV Riva del Garda (TN) 22-25 Settembre 2005; Barbon A.: Regulation of editing and expression of glutamate receptors by antidepressant drugs”
• VIII Congresso AIBG Sirolo, 15/17 settembre 2005:, Barbon A.: “L’innesto di un nervo periferico nel midollo spinale induce la formazione di una sinapsi glutamatergica nel muscolo scheletrico di un ratto”
• VII Congresso AIBG Grado, 23-26 Settembre 2004 ;Barbon A: Editing ed espressione dei recettori per il glutammato in ratti trattati con fenciclidina.
• The RNA world: dalla ricerca alle applicazioni biotecnologiche – Università la Sapienza di Roma Roma 10-11 Giugno 2004; Barbon A., RNA editing: a molecular mechanism for the fine modulation of neuronal transmission”
• V Congresso A.I.B.G. Perugia 1-4 ottobre 2001: Barbon A., Organizzazione genomica del gene GRIK2 ed evidenze per nuove isoforme di splicing alternativo.
Registred patents:
“Metodo di elaborazione e visualizzazione di simboli grafici in un codice colore e relativa rappresentazione su supporti” Autori: Sergio Barlati, Stefano Barlati, Giuseppe Borsani e Alessandro Barbon
Depositato dall’Università degli studi di Brescia all’ufficio italiano brevetti (N°BS2005A000087) in data 13-7-2005 e all’European Patent Office (N° 06115244.3) in data 6 giugno 2006
FULL WORK ADDRESS: Division of Biology and Genetics, Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.
E-MAIL alessandro.barbon@unibs.it
CURRENT POSITION: Full Professor in Applied Biology, Dept. of Molecular and Translational Medicine, University of Brescia
WORK EXPERIENCE:
2021 - now Full Professor in Applied Biology, Dept. of Molecular and Translational Medicine, University of Brescia
2015 – 2021 Associate Professor, Dept. of Molecular and Translational Medicine, University of Brescia
2018 National Scientific Qualification as Full Professor in Applied Biology
2011 - now Group leader of the RNA biology Lab, Dept. of Molecular and Translational Medicine, University of Brescia.
2018 – now Member of the Central Board for the supervision of the Quality of the University of Brescia
2007 – 2012 Member of the Central Research Committee of the University of Brescia
2004 - 2015 Assistant Professor, Dept. of Molecular and Translational Medicine, University of Brescia
2002 - 2003 Postdoctoral Fellow, Dept. of Molecular and Translational Medicine, University of Brescia
EDUCATION AND TRAINING
November 2002: Ph.D in Molecular Genetics applied to Medical Science, University of Brescia
November 1999: Qualifying examination (Esame di Stato all'abilitazione della professione di Biologo)
March 1999: Awarded a four year Ph.D. grant Molecular Genetics applied to Medical Science at Department of Molecular and Translational Medicine, University of Brescia,
September 1998-March 1999: professional training in the Human Genetic lab at the University of Padova
July 1998: University degree in Biology Science cum laude (110/110 e lode), at the University of Padova
July 1993: High School Diploma (diploma di maturità scientifica) with 58 points out of 60
SCIENTIFIC MEMBERSHIPS
2003-now: Member of the Italian Society of Biology and Genetics (AIBG)
2017 - now: Member of the RNA Society
2021-now: Member of the Italian Society of Neuroscience (SINS)
GRANTS
HEAL ITALIA PNRR M4C2 2025-2026 (partecipant): Development of an ORGANoid-Based Platform for CAR-T Validation Using Nanoparticles Mediated mRNA Delivery
Cariplo foundation Grant 2017 (Principal Investigator of Operative Unit): MicroRNAs in Frailty-Associated Cognitive Impairment.
Health and Wealth 2015 projects by University of Brescia (component of Operative Unit; PI of working package): REFrACT – Analysis of the neurobiological mechanisms underlining treatment resistance to psychotropic drugs in innovative cellular models.
PRIN2015 (Principal Investigator of Operative Unit): Risposte maladattative dello stress: studio dei meccanismi che le regolano per identificare nuovi bersagli terapeutici nelle malattie neuropsichiatriche
Progetti Fondazione Banca del Monte di Lombardia-2014 (Co-Principal Investigator): Nuovi target molecolari per la terapia delle discinesie da L-DOPA in modelli animali di malattia di Parkinson: ruolo dei processi di RNA editing dei recettori AMPA
PRIN2012 (Principal Investigator of Operative Unit): Ketamine as a tool to understand the nature of rapid antidepressant action. Relevance for therapy of treatment-resistant depression
PRIN2009 (Principal Investigator of Operative Unit): La sinapsi stressata: Effetti sinaptici dello stress comportamentale e azione degli antidepressivi
2011-Lombardia regional grant (component of Operative Unit; PI of working package): NEDD- Network Enabled drug design
PRIN2007-(component of Operative Unit; PI of working package): Disturbi d’ansia e legati allo stress: nuovi meccanismi e bersagli farmacologici.
2007 – Grant from Ministry of Health (component of Operative Unit, PI of working package): Innovative strategies for depression treatment: novel pharmacological targets and preclinical studies for the personalization of therapy.
PRIN2005- (component of Operative Unit, PI of working package):
PRIN2003- (component of Operative Unit; PI of working package): Meccanismi di Neuroplasticità glutammatergica come bersagli molecolari per lo sviluppo di strategie farmacologiche innovative nei disturbi affettivi :approfondimento dei meccaismi e identificazione di potenziali
PRIN2001- (component of Operative Unit; PI of working package): Meccanismi di Neuroplasticità glutammatergica come bersagli molecolari per lo sviluppo di strategie farmacologiche innovative nei disturbi affettivi.
PUBLICATIONS
70 scientific articles indexed in Pubmed
H-index: 27 Citations: 1630 (source Scopus)
Total Impact Factor > 250
Scopus link: https://www.scopus.com/authid/detail.uri?authorId=6602866116
RESERCH INTEREST:
1) revealing the correlations among RNA metabolism dysregulation, neurological disorders and their pharmacological medications. 2) Uncovering the molecular correlations among post-transcriptional mechanisms. 3) Understanding the biological and molecular mechanisms regulating the activity of the glutamatergic and neutrophic systems in physiological and stress related conditions.
PRESENTATIONS IN NATIONAL/INTERNATIONAL CONGRESSES OR ORGANIZATION OF SCIENTIFIC CONGRESSES
• RNA Metabolism in neurodegenerative diseases, Pavia 27-28 giugno 2019; Barbon A: RNA editing in neurological diseases
• XX Congresso nazionale SIGU Napoli 17-18/11/2017; Barbon A. Glutamate receptor RNA editing in health and disease.
• XVI Congresso Nazionale AIBG Napoli, 26-27/9/2014; Barbon A: Modulation of dendritic AMPA receptor mRNA trafficking by RNA splicing and editing
• XII Congresso AIBG Trento 8-9/10/2010; Barbon A: Acute spinal cord injury persistently reduces R/G RNA editing of AMPA glutamate receptors
• Congresso Spine and Spinal cord 4 luglio 2008; Barbon A: Espressione e RNA editing dei recettori per il glutammato nel midollo spinale
• 7° Convegno FISV Riva del Garda (TN) 22-25 Settembre 2005; Barbon A.: Regulation of editing and expression of glutamate receptors by antidepressant drugs”
• VIII Congresso AIBG Sirolo, 15/17 settembre 2005:, Barbon A.: “L’innesto di un nervo periferico nel midollo spinale induce la formazione di una sinapsi glutamatergica nel muscolo scheletrico di un ratto”
• VII Congresso AIBG Grado, 23-26 Settembre 2004 ;Barbon A: Editing ed espressione dei recettori per il glutammato in ratti trattati con fenciclidina.
• The RNA world: dalla ricerca alle applicazioni biotecnologiche – Università la Sapienza di Roma Roma 10-11 Giugno 2004; Barbon A., RNA editing: a molecular mechanism for the fine modulation of neuronal transmission”
• V Congresso A.I.B.G. Perugia 1-4 ottobre 2001: Barbon A., Organizzazione genomica del gene GRIK2 ed evidenze per nuove isoforme di splicing alternativo.
Registred patents:
“Metodo di elaborazione e visualizzazione di simboli grafici in un codice colore e relativa rappresentazione su supporti” Autori: Sergio Barlati, Stefano Barlati, Giuseppe Borsani e Alessandro Barbon
Depositato dall’Università degli studi di Brescia all’ufficio italiano brevetti (N°BS2005A000087) in data 13-7-2005 e all’European Patent Office (N° 06115244.3) in data 6 giugno 2006
Fields (6)
Free text keywords (3)
RNA
RNA-EDITING
RNA-TRAFFICKING
No Results Found
Research fields (3)
Revealing the correlations among RNA editing dysregulation, neurological disorders and their pharmacological medications
studying the biological and molecular mechanisms regulating the activity of the glutamatergic system
uncovering the molecular correlations among post-transcriptional mechanism such as RNA editing, RNA splicing and RNA trafficking
No Results Found
Member of
RNA Biology
GroupCollaborates with
Other research activities
APPROCCI BIOTECNOLOGICI DI FRONTIERA PER LA SALUTE, PER L'AMBIENTE E L'INDUSTRIA
Bando Ministero Università e della Ricerca
Project
Scientific Manager
No Results Found