Person
RUSNATI MARCO
Docenti di ruolo di Ia fascia
Course Catalogue:
study of the macromolecular interactions (protein-protein. protein-sugars) by surface plasmon resonance and microscale thermophoresis in oncology and virology.
study of the cellular and molecular mechanisms of tumor angiogenesis and cystic fibrosis
drug dicovery in oncology, virology and cystic fibrosis
Communications
Curriculum Vitae
Bibliography:
•Prof. Marco Rusnati has received his PhD in Biological Sciences at the School of Biology, University of Milan, Italy, in 1985 (110/110 cum laude).
•Currently, he is working as Full Professor at the Section of Experimental Oncology and Immunology, Dept. of Molecular and Translational Medicine, University of Brescia, where he is teaching in several courses of the area of pathology and immunology since 1992.
•His work has been founded by several national grant agencies including the Italian Foundation for cystic fibrosis, AIRC, MIUR and ISS.
since 2010 is responsible of the Macromolecular Interaction Analisis Unit (MIAU) at the University of Brescia
•He has partecipating to 209 national and international congresses and has given 95 invited speeches.
•He is serving as an editorial member of The Open Microcirculation & Microvascular Journal, The Journal of Bioengineering & Biomedical Science, Current Angiogenesis.
•He acts as reviewer for up to 173 reputed journals including Blood and Oncogene.
•He has authored 22 book's chapters and 161 research articles on peer-reviewed journals [h index= 56 (scopus), 61 (google scholar), cumulative impact factor=1041).
Research interest:
•Study of molecular interaction by surface plasmon resonance.
•Purification and characterization of angiogenic growth factors (FGFs, VEGF, Gremlin, ephrin/ephrin receptor system), identification of their functional domains and of their interaction with receptors and co-receptors present onto the cell-membrane or in the extracellular matrix of endothelium.
•Biological activities of HIV proteins Tat, gp120 and p17, their interaction with cellular receptors and extracellular matrix.
•development of inhibitor of HIV and other viruses (HPV, RSV, HSV, SARS-CoV-2).
•drug discovery in cystic fibrosis.
•Prof. Marco Rusnati has received his PhD in Biological Sciences at the School of Biology, University of Milan, Italy, in 1985 (110/110 cum laude).
•Currently, he is working as Full Professor at the Section of Experimental Oncology and Immunology, Dept. of Molecular and Translational Medicine, University of Brescia, where he is teaching in several courses of the area of pathology and immunology since 1992.
•His work has been founded by several national grant agencies including the Italian Foundation for cystic fibrosis, AIRC, MIUR and ISS.
since 2010 is responsible of the Macromolecular Interaction Analisis Unit (MIAU) at the University of Brescia
•He has partecipating to 209 national and international congresses and has given 95 invited speeches.
•He is serving as an editorial member of The Open Microcirculation & Microvascular Journal, The Journal of Bioengineering & Biomedical Science, Current Angiogenesis.
•He acts as reviewer for up to 173 reputed journals including Blood and Oncogene.
•He has authored 22 book's chapters and 161 research articles on peer-reviewed journals [h index= 56 (scopus), 61 (google scholar), cumulative impact factor=1041).
Research interest:
•Study of molecular interaction by surface plasmon resonance.
•Purification and characterization of angiogenic growth factors (FGFs, VEGF, Gremlin, ephrin/ephrin receptor system), identification of their functional domains and of their interaction with receptors and co-receptors present onto the cell-membrane or in the extracellular matrix of endothelium.
•Biological activities of HIV proteins Tat, gp120 and p17, their interaction with cellular receptors and extracellular matrix.
•development of inhibitor of HIV and other viruses (HPV, RSV, HSV, SARS-CoV-2).
•drug discovery in cystic fibrosis.
Fields (11)
Free text keywords
SURFACE PLASMON RESONANCE MOLECULAR INTERACTION, ENDOTHELIAL CELLS, ANGIOGENESIS, HIV-1, HEPARAN SULFATE PROTEOGLYCANS
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Research fields (10)
HIV: Identification of Hiv-1 Tat functional domains and of their interaction with receptors and co-receptors present onto the cell-membrane or in the extracellular matrix of endothelium and lymphoid cells: identification of glycan-based inhibitors of Tat pathological activities
HIV: study of other HIV proteins (gp120, p17)
angiogenesis: Purification and characterization of FGFs, identification of their functional domains and of their interaction with receptors and co-receptors present onto the cell-membrane or in the extracellular matrix of endothelium.
angiogenesis: study of the molecular bases of the interaction of other angiogenic growth factors ((VEGF, gremlin, Ephrin system) with their cell receptors and extracelklular matrix components. identification of natural or synthetic antagonists for the development of antiangiogenic drugs
biosensor: development of new biosensors and related material
biosensors: surface plasmon resonance for the study of biological interactions of angiogenic growth factors and viral proteins: identification of anticancer or antiviral compounds
cystic fibrosis: set up of dedicated biosensors, identification of new drugs
hepatic chemical carcinogenesis
purification and characterization of D-amino acid oxidase (DAAO)
study of other human viruses (HPV, RSV, HSV). identification of putative antiviral drugs.
to date, the know-how developed on the above mentioned viruses is applied to the study of SARS-CoV2
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Member of
Other research activities
APPROCCI BIOTECNOLOGICI DI FRONTIERA PER LA SALUTE, PER L'AMBIENTE E L'INDUSTRIA
Bando Ministero Università e della Ricerca
Project
Scientific Manager
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