Extracellular vesicles (EVs) have emerged as a major focus of biomedical research due to their considerable potential as non-invasive biomarkers and as biocompatible drug delivery systems. EVs exhibit excellent biocompatibility and possess intrinsic targeting capabilities, with several specific targeting mechanisms already described. However, the molecular processes governing cargo delivery remain poorly understood and are often critical determinants of the final functional outcome.
This network brings together complementary expertise to investigate these mechanisms in depth through the integration of advanced in vitro models, studies in model organisms, and comparative analyses with synthetic nanoparticles. By combining these approaches, we aim to elucidate the fundamental principles underlying EV cargo transfer, cellular uptake, and biological activity.
To facilitate the translation of EV-based technologies into clinical applications, the network also includes groups specializing in the production and characterization of mesenchymal stromal cell (MSC)-derived EVs, as well as teams developing biomaterial scaffolds and implantation strategies to optimize EV delivery and therapeutic efficacy.
This network brings together complementary expertise to investigate these mechanisms in depth through the integration of advanced in vitro models, studies in model organisms, and comparative analyses with synthetic nanoparticles. By combining these approaches, we aim to elucidate the fundamental principles underlying EV cargo transfer, cellular uptake, and biological activity.
To facilitate the translation of EV-based technologies into clinical applications, the network also includes groups specializing in the production and characterization of mesenchymal stromal cell (MSC)-derived EVs, as well as teams developing biomaterial scaffolds and implantation strategies to optimize EV delivery and therapeutic efficacy.