Renal Function Impairment Below Safety Limits Correlates With Cancer-specific Mortality in Localized Renal Cell Carcinoma: Results From a Single-center Study

Below 85 mL/min, an inverse linear correlation between the estimated glomular filtration rate (eGFR) and cancer-specific mortality exists in stage I to II renal cell carcinoma. Conversely, above this breakpoint, as well as in stage III to IV disease, regardless of eGFR, no significant relationship exists. These findings suggest an oncologic role of eGFR in stage I to II renal cell carcinomas. Here, nephron-sparing approaches should be preferred, unless extirpative surgery could equally warrant eGFR preservation.