DEL PRETE ANNALISA

Name: Annalisa DEL PRETE
Sex: Female
Nationality: Italian
Date of birth: March 16, 1968
Place of birth: Campi Sal.na (LE), Italy
Marital status: Married
Foreign language: English
Position Associate Professor of Clinical Pathology (SSD MED05)


Work address:
Department of Molecular and Translational Medicine
University of Brescia
Viale Europa 11
25123 Brescia
Phone +39-030-371-7752
Fax +39-030-371-7747
E-mail: annalisa.delprete@unibs.it

Education:
2007: Specialist in Allergology and Clinical Immunology
2003: PhD, University of Bari, Italy
1999: Specialist in Clinical Biochemistry, University of Bari, Italy
1995: M.D., University of Bari, Italy

Membership:
2006: Italian Society of Allergology and Clinical Immunology (SIAIC)
2003: Italian Society of Clinical Biochemistry
2000: Italian Society of Immunology, Clinical Immunology and Allergology (SIICA)

Prize
2002: VI Roche Milano Ricerche Prize for the Research in Immunology during the 1st National Conference SIICA, Montecatini Terme, May 8-11.

Fellowship
2001: “Samanin’s Fellowship”, “Mario Negri” Institute, Milan, Italy

Research Experience
2012-present: Researcher at the University of Brescia and at the IRCCS Istituto Clinico Humanitas-Rozzano (MI)
2007-2012: Research work in collaboration with the Lab of Immunology directed by Prof Mantovani, under the supervision of Prof Sozzani at the IRCCS Istituto Clinico Humanitas-Rozzano (MI) and at the University of Bari
2005-2006: Visiting scientist, Department of Immunology and Microbiology, University of Louisville, Kentucky, USA
1999-2003: Ph.D, Laboratory of inflammation and Signal Transduction, “Mario Negri” Institute, Milan, Italy
1995-1999: Specialization in Clinical Biochemistry, University of Bari, Italy
1993-1995: Attending student, Dep. Biomedical Science and Human Oncology, University of Bari, Italy

Scientific activity
Dr Annalisa Del Prete carried out her research activity focusing on the study of dendritic cell biology, in particular the in vitro generation of human dendritic cells derived from circulating monocytes and from medullary CD34 + precursors and to the subsequent phenotypic and functional characterization of this cells by in vitro and in vivo experimental approaches.
Dr. Del Prete has carried out such research projects in collaboration with prestigious research groups, in particular the group directed by Prof. Silvano Sozzani at the Institute of Pharmacological Research "Mario Negri" (Milan) and at the University of Brescia. She also worked as visiting scientist at the James Graham Brown Cancer Center, University of Louisville Health Sciences Center (Kentucky, USA), in the laboratory of Prof. Haribabu Bodduluri, focusing on the study of the role of lipid mediators in inflammatory processes using genetic models. Subsequently, she dedicated to the characterization of the role of mitochondria in the processes of differentiation and maturation of dendritic cells at the Department of Biomedical Sciences and Human Oncology of the University of Bari "Aldo Moro". In recent years, at the Department of Molecular and Translational Medicine of the University of Brescia and in collaboration with the Humanitas Clinical Institute of Rozzano (MI), her scientific interests have been focused on the study of the pathogenetic role of immune system dysfunction in autoimmunity and cancer.

FUNDINGS
PRIN2007 as Principal Investigator of the project entitled: “Identification of new pathways involved in the modulation of dendritic cell migration as potential therapeutic targets in inflammatory diseases”
Progetto Giovani Ricercatori del Ministero della Salute 2008, Associate Investigator of the project entitled “Il ruolo del sistema linfatico nella patogenesi delle malattie infiammatorie croniche intestinali: un nuovo target per intervento terapeutico", (PI: Dr. S. Danese, Istituto Clinico Humanitas
PRIN2009, Associate Investigator of the project entitled “Role of chemerin/CCRL2 axis in angiogenesis-related inflammation: a potential new pharmacological target in rheumatoid arthritis”.

Bibliometric indices (Scopus)
Number of publications: 33
Sum of the times cited: 1335
H-index: 15

Selected pubblications
Mazzotti C, Gagliostro V, Bosisio D, Del Prete A, Tiberio L, Thelen M, Sozzani S. The Atypical Receptor CCRL2 (C-C Chemokine Receptor-Like 2) Does Not Act As a Decoy Receptor in Endothelial Cells. Front Immunol. 2017;8:1233

Sozzani S, Del Prete A, Bosisio D. Dendritic cell recruitment and activation in autoimmunity.
J Autoimmun. 2017 Dec;85:126-140.

Del Prete A, Martínez-Muñoz L, Mazzon C, Toffali L, Sozio F, Bosisio B, Gazzurelli L, Tiberio L, Scanziani E, Vecchi A, Laudanna C, Mellado M, Mantovani A, Sozzani S. The atypical receptor CCRL2 is required for CXCR2-dependent neutrophil recruitment and tissue damage. Blood. 130(10):1223-1234.

Salvi V, Sozio F, Sozzani S, Del Prete A. Role of Atypical Chemokine Receptors in Microglial Activation and Polarization. Frontiers in Aging Neuroscience. 2017 May; 9: 148. https://doi.org/10.3389/fnagi.2017.00148.

Del Prete A, Schioppa T, Tiberio L, Stabile H, Sozzani S. Leukocyte trafficking in tumor microenvironment. Curr Opin Pharmacol. 2017 May 31;35:40-47. doi: 10.1016/j.coph.2017.05.004.

Mazzon C*, Zanotti L*, Wang L*, Del Prete A*, Fontana E, Salvi V, Poliani PL, Sozzani S. CCRL2 regulates M1/M2 polarization during EAE recovery phase. J Leukoc Biol. 2016 Jun;99(6):1027-33. doi: 10.1189/jlb.3MA0915-444RR. *the authors equally contributed.

Sozzani S, Del Prete A, Bonecchi R, Locati M. Chemokines as effector and target molecules in vascular biology. Cardiovasc Res. 2015 Aug 1;107(3):364-72. doi: 10.1093/cvr/cvv150.

Sozzani S, Del Prete A. Chemokines as relay signals in human dendritic cell migration: serum amyloid A kicks off chemotaxis. Eur J Immunol. 2015 Jan;45(1):40-3. doi: 10.1002/eji.201445305.

Gonzalvo-Feo S*, Del Prete A*, Pruenster M, Salvi V, Wang L, Sironi M, Bierschenk S, Sperandio M, Vecchi A, Sozzani S. Endothelial cell-derived chemerin promotes dendritic cell transmigration. J Immunol. 2014 Mar 1;192(5):2366-73. doi: 10.4049/jimmunol.1302028. *the authors equally contributed to the work.

Del Prete A, Bonecchi R, Vecchi A, Mantovani A, Sozzani S. CCRL2, a fringe member of the atypical chemoattractant receptor family. Eur J Immunol. 2013 Jun;43(6):1418-22. doi: 10.1002/eji.201243179.

Zaccagnino P, Saltarella M, Maiorano S, Gaballo A, Santoro G, Nico B, Lorusso M, Del Prete A. An active mitochondrial biogenesis occurs during dendritic cell differentiation. Int J Biochem Cell Biol. 2012 Nov;44(11):1962-9. doi:10.1016/j.biocel.2012.07.024.

De Palma G, Castellano G, Del Prete A, Sozzani S, Fiore N, Loverre A,Parmentier M, Gesualdo L, Grandaliano G, Schena FP. The possible role ofChemR23/Chemerin axis in the recruitment of dendritic cells in lupus nephritis. Kidney Int. 2011 Jun;79(11):1228-35. doi: 10.1038/ki.2011.32.

Otero K, Vecchi A, Hirsch E, Vermi W, Del Prete A, Gonzalvo-Feo S, Garlanda C, Azzolino A, Salogni L, Lloyd CM, Facchetti F, Mantovani A, Sozzani S. Non-redundant role of CCRL2 in lung dendritic cell trafficking. Blood. 2010 Oct 21;116(16):2942-9. doi: 10.1182/blood-2009-12-259903.

Sozzani S, Vermi W, Del Prete A, Facchetti F. Trafficking properties of plasmacytoid dendritic cells in health and disease. Trends Immunol. 2010 Jul;31(7):270-7. doi: 10.1016/j.it.2010.05.004.

Del Prete A, Zaccagnino P, Di Paola M, Saltarella M, Oliveros Celis C, Nico B, Santoro G, Lorusso M. Role of mitochondria and reactive oxygen species in dendritic cell differentiation and functions. Free Radic Biol Med. 2008 Apr 1;44(7):1443-51. doi: 10.1016/j.freeradbiomed.2007.12.037.

Del Prete A, Shao WH, Mitola S, Santoro G, Sozzani S, Haribabu B. Regulation of dendritic cell migration and adaptive immune response by leukotriene B4 receptors: a role for LTB4 in up-regulation of CCR7 expression and function. Blood. 2007 Jan 15;109(2):626-31. doi:10.1182/blood-2006-02-003665.

Shao WH, Del Prete A, Bock CB, Haribabu B. Targeted disruption of leukotriene B4 receptors BLT1 and BLT2: a critical role for BLT1 in collagen-induced arthritis in mice. J Immunol. 2006 May 15;176(10):6254-61.

Del Prete A, Locati M, Otero K, Riboldi E, Mantovani A, Vecchi A, Sozzani S. Migration of dendritic cells across blood and lymphatic endothelial barriers. Thromb Haemost. 2006 an;95(1):22-8.

Cera MR*, Del Prete A*, Vecchi A, Corada M, Martin-Padura I, Motoike T, Tonetti P, Bazzoni G, Vermi W, Gentili F, Bernasconi S, Sato TN, Mantovani A, Dejana E. Increased DC trafficking to lymph nodes and contact hypersensitivity in junctional adhesion molecule-A-deficient mice. J. Clin. Invest. 2004;114 729-738. *the authors equally contributed.

Del Prete A, Vermi W, Dander E, Otero K, Barberis L, Luini W, Bernasconi S, Sironi M, Santoro A, Garlanda C, Facchetti F, Wymann MP, Vecchi A, Hirsch E, Mantovani A, Sozzani S. Defective dendritic cell migration and activation of adaptive immunity in PI3Kgamma-deficient mice. EMBO J. 2004 Sep 1;23(17):3505-15.

Chieppa M, Bianchi G, Doni A, Del Prete A, Sironi M, Laskarin G, Monti P, Piemonti L, Biondi A, Mantovani A, Introna M, Allavena P. Cross-linking of the mannose receptor on monocyte-derived dendritic cells activates an anti-inflammatory immunosuppressive program. The Journal of. Immunology; 2003; 171: 4552-4560.

Vulcano M, Albanesi C, Stoppacciaro A, Bagnati R, D'Amico G, Struyf S, Transidico P, Bonecchi R, Del Prete A, Allavena P, Ruco LP, Chiabrando C, Girolomoni G, Mantovani A, Sozzani S. Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo. Eur J Immunol. 2001 Mar;31(3):812-22.