Global validation of the WSES Sepsis Severity Score for patients with complicated intra-abdominal infections: a prospective multicentre study (WISS Study).
Articolo
Data di Pubblicazione:
2015
Abstract:
BACKGROUND:
To validate a new practical Sepsis Severity Score for patients with complicated intra-abdominal infections (cIAIs) including the clinical conditions at the admission (severe sepsis/septic shock), the origin of the cIAIs, the delay in source control, the setting of acquisition and any risk factors such as age and immunosuppression.
METHODS:
The WISS study (WSES cIAIs Score Study) is a multicenter observational study underwent in 132 medical institutions worldwide during a four-month study period (October 2014-February 2015). Four thousand five hundred thirty-three patients with a mean age of 51.2 years (range 18-99) were enrolled in the WISS study.
RESULTS:
Univariate analysis has shown that all factors that were previously included in the WSES Sepsis Severity Score were highly statistically significant between those who died and those who survived (p < 0.0001). The multivariate logistic regression model was highly significant (p < 0.0001, R2 = 0.54) and showed that all these factors were independent in predicting mortality of sepsis. Receiver Operator Curve has shown that the WSES Severity Sepsis Score had an excellent prediction for mortality. A score above 5.5 was the best predictor of mortality having a sensitivity of 89.2 %, a specificity of 83.5 % and a positive likelihood ratio of 5.4.
CONCLUSIONS:
WSES Sepsis Severity Score for patients with complicated Intra-abdominal infections can be used on global level. It has shown high sensitivity, specificity, and likelihood ratio that may help us in making clinical decision
To validate a new practical Sepsis Severity Score for patients with complicated intra-abdominal infections (cIAIs) including the clinical conditions at the admission (severe sepsis/septic shock), the origin of the cIAIs, the delay in source control, the setting of acquisition and any risk factors such as age and immunosuppression.
METHODS:
The WISS study (WSES cIAIs Score Study) is a multicenter observational study underwent in 132 medical institutions worldwide during a four-month study period (October 2014-February 2015). Four thousand five hundred thirty-three patients with a mean age of 51.2 years (range 18-99) were enrolled in the WISS study.
RESULTS:
Univariate analysis has shown that all factors that were previously included in the WSES Sepsis Severity Score were highly statistically significant between those who died and those who survived (p < 0.0001). The multivariate logistic regression model was highly significant (p < 0.0001, R2 = 0.54) and showed that all these factors were independent in predicting mortality of sepsis. Receiver Operator Curve has shown that the WSES Severity Sepsis Score had an excellent prediction for mortality. A score above 5.5 was the best predictor of mortality having a sensitivity of 89.2 %, a specificity of 83.5 % and a positive likelihood ratio of 5.4.
CONCLUSIONS:
WSES Sepsis Severity Score for patients with complicated Intra-abdominal infections can be used on global level. It has shown high sensitivity, specificity, and likelihood ratio that may help us in making clinical decision
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Infections, Intra-abdominal Sepsis; Septic shock
Elenco autori:
Sartelli, M; Abu Zidan, Fm; Catena, F; Griffiths, Ea; Di Saverio, S; Coimbra, R; Ordoñez, Ca; Leppaniemi, A; Fraga, Gp; Coccolini, F; Agresta, F; Abbas, A; Abdel Kader, S; Agboola, J; Amhed, A; Ajibade, A; Akkucuk, S; Alharthi, B; Anyfantakis, D; Augustin, G; Baiocchi, Gian Luca; Bala, M; Baraket, O; Bayrak, S; Bellanova, G; Beltràn, Ma; Bini, R; Boal, M; Borodach, Av; Bouliaris, K; Branger, F; Brunelli, D; Catani, M; Che Jusoh, A; Chichom Mefire, A; Cocorullo, G; Colak, E; Costa, D; Costa, S; Cui, Y; Curca, Gl; Curry, T; Das, K; Delibegovic, S; Demetrashvili, Z; Di Carlo, I; Drozdova, N; El Zalabany, T; Enani, Ma; Faro, M; Gachabayov, M; Giménez Maurel, T; Gkiokas, G; Gomes, Ca; Gonsaga, Ra; Guercioni, G; Guner, A; Gupta, S; Gutierrez, S; Hutan, M; Ioannidis, O; Isik, A; Izawa, Y; Jain, Sa; Jokubauskas, M; Karamarkovic, A; Kauhanen, S; Kaushik, R; Kenig, J; Khokha, V; Kim, Ji; Kong, V; Koshy, R; Krasniqi, A; Kshirsagar, A; Kuliesius, Z; Lasithiotakis, K; Leão, P; Lee, Jg; Leon, M; Lizarazu Pérez, A; Lohsiriwat, V; López Tomassetti Fernandez, E; Lostoridis, E; Mn, R; Major, P; Marinis, A; Marrelli, D; Martinez Perez, A; Marwah, S; Mcfarlane, M; Melo, Rb; Mesina, C; Michalopoulos, N; Moldovanu, R; Mouaqit, O; Munyika, A; Negoi, I; Nikolopoulos, I; Nita, Ge; Olaoye, I; Omari, A; Ossa, Pr; Ozkan, Z; Padmakumar, R; Pata, F; Pereira Junior, Ga; Pereira, J; Pintar, T; Pouggouras, K; Prabhu, V; Rausei, S; Rems, M; Rios Cruz, D; Sakakushev, B; Sánchez de Molina, Ml; Seretis, C; Shelat, V; Simões, Rl; Sinibaldi, G; Skrovina, M; Smirnov, D; Spyropoulos, C; Tepp, J; Tezcaner, T; Tolonen, M; Torba, M; Ulrych, J; Uzunoglu, My; van Dellen, D; van Ramshorst, Gh; Vasquez, G; Venara, A; Vereczkei, A; Vettoretto, N; Vlad, N; Yadav, Sk; Yilmaz, Tu; Yuan, Kc; Zachariah, Sk; Zida, M; Zilinskas, J; Ansaloni, L.
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