Impact of the dynamic culture condition in the RCCS™ bioreactor on a three-dimensional model of bone formation
Articolo
Data di Pubblicazione:
2011
Abstract:
The dynamic, fluid-filled RCCS™ bioreactor, based on the operational principle of relative micro-gravity condition,
is a new efficient system devised to perform long-term three-dimensional (3D) culture of cells and tissue explants. In
the present study, we evaluated the impact of the RCCS™-produced hydrodynamic condition on an innovative 3D in
vitro model of osteocytes’ differentiation and bone matrix formation, obtained by coupling primary human
osteoblasts with biphasic calcium phosphate (BCP) ceramic particles.
is a new efficient system devised to perform long-term three-dimensional (3D) culture of cells and tissue explants. In
the present study, we evaluated the impact of the RCCS™-produced hydrodynamic condition on an innovative 3D in
vitro model of osteocytes’ differentiation and bone matrix formation, obtained by coupling primary human
osteoblasts with biphasic calcium phosphate (BCP) ceramic particles.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
RCCS™ bioreactor, dynamic culture, bone tissue engineering, 3D culture, biphasic calcium phosphate, bone matrix,
human osteocytes.
Elenco autori:
Mazzoleni, Giovanna; Boukhechba, F.; Steimberg, Nathalie; Boniotti1, J.; Bouler, J. M.; Rochet, N.
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