A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
Articolo
Data di Pubblicazione:
2010
Abstract:
We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Arylamine N-Acetyltransferase; Chromosome Mapping; Chromosomes; Human; Pair 18; Pair 2; Pair 22; Europe; Family; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Incidence; Male; Neoplasm Staging; Polymorphism; Single Nucleotide; Risk Assessment; Risk Factors; Sex Characteristics; Smoking; Spain; United States; Urinary Bladder Neoplasms
Elenco autori:
Rothman, N; Garcia Closas, M; Chatterjee, N; Malats, N; Wu, X; Figueroa, Jd; Real, Fx; Den Berg, Dv; Matullo, G; Baris, D; Thun, M; Kiemeney, L; Vineis, P; Vivo, Id; Albanes, D; Purdue, Mp; Rafnar, T; Ma, Hildebrandt; Kiltie, Ae; Cussenot, O; Golka, K; Kumar, R; Taylor, Ja; Mayordomo, Ji; Jacobs, Kb; Kogevinas, M; Hutchinson, A; Wang, Z; Fu, Y; Prokunina Olsson, L; Burdett, L; Yeager, M; Wheeler, W; Tardón, A; Serra, C; Carrato, A; García Closas, R; Lloreta, J; Johnson, A; Schwenn, M; Karagas, Mr; Schned, A; Andriole, G; Grubb, R; Black, A; Jacobs, Ej; Diver, Wr; Gapstur, Sm; Weinstein, Sj; Virtamo, J; Cortessis, Vk; Gago Dominguez, M; Pike, Mc; Stern, Mc; Yuan, J; Hunter, Dj; Mcgrath, M; Dinney, Cp; Czerniak, B; Chen, M; Yang, H; Vermeulen, Sh; Aben, Kk; Witjes, Ja; Makkinje, Rr; Sulem, P; Besenbacher, S; Stefansson, K; Riboli, E; Brennan, P; Panico, S; Navarro, C; Allen, Ne; Bueno de Mesquita, Hb; Trichopoulos, D; Caporaso, N; Landi, Mt; Canzian, F; Ljungberg, B; Tjonneland, A; Clavel Chapelon, F; Bishop, Dt; Teo, Mt; Knowles, Ma; Guarrera, S; Polidoro, S; Ricceri, F; Sacerdote, C; Allione, A; Cancel Tassin, G; Selinski, S; Hengstler, Jg; Dietrich, H; Fletcher, T; Rudnai, P; Gurzau, E; Koppova, K; Bolick, Sc; Godfrey, A; Xu, Z; Sanz Velez, Ji; García Prats, Md; Sanchez, M; Valdivia, G; Porru, Stefano; Benhamou, S; Hoover, Rn; Fraumeni, Jf; Silverman, Dt; Chanock, Sj
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