Low molecular weight end-functionalized poly(N-vinylpyrrolidinone) for the modification of polypeptide aminogroups

New monofunctionalized amphiphilic oligomers, poly (N-vinyl
pyrrolidinones) with an hydroxyl end group, were prepared by radical
polymerization with 2-isopropoxyethanol, fractionated by both gel-permeation
chromatography and fractional precipitation. The terminal hydroxyl group oligomers
was activated and reacted with the amino groups of a model peptide, and a protein.
These hydroxylated oligomers were also converted to carboxylate end group which
were also activated and used as protein and peptide modifying agents.
New monofunctionalized amphiphilic oligomers, poly (N-vinyl pyrrolidionones) with
an hydroxyl end group, were prepared by radical polymerization with 2-
isopropoxyethanol, fractionated by both gel-permeation chromatography and
fractional precipitation. The terminal hydroxyl group oligomers was activated and
reacted with the amino groups of a model peptide, and a protein. These
hydroxylated oligomers were also converted to carboxylate end group which were
also activated and used as protein and peptide modifying agents.