COVID-19 vaccination-related delayed adverse events among people with rheumatoid arthritis: results from the international COVAD survey
Articolo
Data di Pubblicazione:
2024
Abstract:
This study aimed to assess COVID-19 vaccination-related AEs in patients with rheumatoid arthritis (RA), in the COVID-19 Vaccination in Autoimmune Diseases (COVAD)-2 study. An online international cross-sectional survey captured self-reported data on COVID-19 vaccination-related adverse events (AEs) in people with RA, autoimmune diseases (AIDs; rheumatic [r] and non-rheumatic [nr]) and healthy controls (HCs). The survey was circulated by the COVAD study group, comprising 157 collaborators across 106 countries, from February to June 2022. Delayed AEs among RA were compared with other rAIDs, nrAIDs and HCs using multivariable binary regression. A total of 7203 participants were included (1423 [19.7%] RA, 2620 [36.4%] rAIDs, 426 [5.9%] nrAIDs, 2734 [38%] HCs), with 75% female. Compared to HCs, individuals with RA reported higher overall major AEs [OR 1.3 (1.0-1.7)], and an increased number of several minor AEs. Compared to nrAIDs, people with RA had several increased reported minor AEs including myalgia and joint pain. People with active RA had increased major AEs [OR 1.8 (1.1-3.0)] and hospitalisation [OR 4.1 (1.3 - 13.3)] compared to inactive RA. RA patients without autoimmune comorbidities had significantly fewer major and minor AEs than those with other rAIDs. A decreased incidence of hospitalisation was seen in patients taking methotrexate or TNF inhibitors compared to patients not taking these medications. COVID-19 vaccination is associated with minimal to no risks of delayed AEs in patients with RA compared to HCs, and fewer compared to other rAIDs. Active RA and presence of co-existing rAIDs were associated with an increased risk of delayed AEs.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Coronavirus; Rheumatoid arthritis; Survey; Vaccination.
Elenco autori:
M, Dey; B, Doskaliuk; I, Parodis; J, Lindblom; C, Wincup; M, Joshi; D, Dey; W, Katchamart; E, Kadam; P, Sen; Sk, Shinjo; A, Nune; Pa, Goo; N, Ziade; Ym, Chen; Ls, Traboco; Cet, Gutiérrez; B, Vaidya; V, Agarwal; L, Gupta; E, Nikiphorou; COVAD Study Group R Naveen, COVAD Study Group.; Saha, Sreoshy; Lyn Tan, Ai; Ziade, Nelly; Kuwana, Masataka; Yoshida, Akira; Yomono, Keina; Pauling, John D.; Makol, Ashima; Day, Jessica; Chatterjee, Tulika; Cavagna, Lorenzo; Agarwal, Vishwesh; Milchert, Marcin; Distler, Oliver; Chinoy, Hector; Valikova, Tsvetelina; Edgar Gracia-Ramos, Abraham; Knitza, Johannes; Patel, Aarat; Barman, Bhupen; Adrian Zamora Tehozol, Erick; Rojas Serrano, Jorge; García-De La Torre, Ignacio; Colunga-Pedraza, Iris J.; Merayo-Chalico, Javier; Celestine Chibuzo, Okwara; Shumnalieva, Russka; Santos Hoff, Leonardo; Kibbi, Lina; Halabi, Hussein; Tanveer Hasan, A. T. M.; Caballero-Uribe, Carlo V.; Lilleker, James B.; Salim, Babur; Gheita, Tamer; Saavedra, Miguel A.; Kardes, Sinan; Andreoli, Laura; Lini, Daniele; Schreiber, Karen; Nagy Vince, Melinda; Preet Singh, Yogesh; Ranjan, Rajiv; Jain, Avinash; Pandya, Sapan C.; Kumar Pilania, Rakesh; Sharma, Aman; Manesh Manoj, M.; Gupta, Vikas; Kavadichanda, Chengappa G.; Sekhar Patro, Pradeepta; Ajmani, Sajal; Phatak, Sanat; Prosad Goswami, Rudra; Chandra Chowdhury, Abhra; Jacob Mathew, Ashish; Shenoy, Padnamabha; Asranna, Ajay; Talari Bommakanti, Keerthi; Shukla, Anuj; Pande, Arunkumar R.; Chandwar, Kunal; Ghodke, Akanksha; Boro, Hiya; Zahid Fazal, Zoha; Üsküdar Cansu, Döndü; Yıldırım, Reşit; Yuri Gasparyan, Armen; Papa, Nicoletta; Sambataro, Gianluca; Fabiola, Atzeni; Govoni, Marcello; Parisi, Simone; Bartoloni Bocci, Elena; Domenico Sebastiani, Gian; Fusaro, Enrico; Sebastiani, Marco; Quartuccio, Luca; Franceschini, Franco; Paolo Sainaghi, Pier; Orsolini, Giovanni; Angelis, Rossella; Giovanna Danielli, Maria; Venerito, Vincenzo; Grignaschi, Silvia; Giollo, Alessandro; Alluno, Alessia; Ioannone, Florenzo; Fornaro, Marco; Anggoro Kusumo Wibowo, Suryo; Loarce-Martos, Jesús; Prieto-González, Sergio; Aranega Gonzalez, Raquel; Nakashima, Ran; Sato, Shinji; Kimura, Naoki; Kaneko, Yuko; Gono, Takahisa; Tomaras, Stylianos; Nikolai Proft, Fabian; Holzer, Marie-Therese; Aleksandrovna Gromova, Margarita; Aharonov, Or; Griger, Zoltán; Hmamouchi, Ihsane; Bouchti, Imane; Baba, Zineb; Giannini, Margherita; Maurier, François; Campagne, Julien; Meyer, Alain; Langguth, Daman; Limaye, Vidya; Needham, Merrilee; Srivastav, Nilesh; Hudson, Marie; Landon-Cardinal, Océane; Gerardo Rojas Zuleta, Wilmer; Arbeláez, Álvaro; Cajas, Javier; António Pereira Silva, José; Eurico Fonseca, João; Zimba, Olena; Bohdana, Doskaliuk; Ima-Edomwonyi, Uyi; Dedeke, Ibukunoluwa; Airenakho, Emorinken; Henry Madu, Nwankwo; Yerima, Abubakar; Olaosebikan, Hakeem; Becky, A.; Devi Koussougbo, Oruma; Palalane, Elisa; So, Ho; Francisco Ugarte-Gil, Manuel; Chinchay, Lyn; Proaño Bernaola, José; Pimentel, Victorio; Mohammed Fathi, Hanan; Mohammed, Reem Hamdy A.; Harifi, Ghita; Fuentes-Silva, Yurilís; Cabriza, Karoll; Losanto, Jonathan; Colaman, Nelly; Cachafeiro-Vilar, Antonio; Guerra Bautista, Generoso; Julio Giraldo Ho, Enrique; Stange Nunez, Lilith; Cristian, Vergara M.; Then Báez, Jossiell; Alonzo, Hugo; Benito Santiago Pastelin, Carlos; García Salinas, Rodrigo; Quiñónez Obiols, Alejandro; Chávez, Nilmo; Bran Ordóñez, Andrea; Alberto Reyes Llerena, Gil; Sierra-Zorita, Radames; Arrieta, Dina; Romero Hidalgo, Eduardo; Saenz, Ricardo; Idania, Escalante M.; Calapaqui, Wendy; Quezada &, Ivonne; Arredondo, Gabriela
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