Breakthrough SARS‑CoV‑2 infection in fully vaccinated patients with systemic lupus erythematosus: results from the COVID‑19 Vaccination in Autoimmune Disease (COVAD) study
Articolo
Data di Pubblicazione:
2024
Abstract:
Objective: To determine the occurrence of breakthrough COVID-19 infections (BIs) in patients with systemic lupus erythematosus (SLE) compared with patients with other rheumatic autoimmune diseases (rAIDs), patients with non-rheumatic autoimmune diseases (nrAIDs), and healthy controls (HCs).
Methods: The study was based on data from 7035 fully vaccinated respondents to the online COVAD questionnaire with SLE (N = 852), rAIDs (N = 3098), or nrAIDs (N = 414), and HCs (N = 2671). BI was defined as COVID-19 infection occurring in individuals vaccinated with ≥ 2 doses (or 1 dose of J&J) ≥ 14 days after vaccination and not after 6 months since the last vaccine dose. Data were analysed using linear and logistic regression models.
Results: A total of 91/852 (10.7%) SLE patients reported at least one BI. The frequency of BIs in SLE patients was comparable to that among HCs (277/2671; p = 0.847) and patients with nrAID (39/414; p = 0.552) but higher than that among patients with other rAIDs (235/3098; p = 0.005). No demographic factors or treatments were associated with BIs in SLE patients (p ≥ 0.05 for all). Joint pain was more frequent in SLE patients than in HCs (odds ratio [OR]: 3.38; 95% confidence interval [CI]: 1.89-6.04; p < 0.001) or nrAID patients (OR: 2.44; 95% CI: 1.04-5.75; p = 0.041). Patient with SLE did not report a higher frequency of hospitalisation or need for advanced treatment for COVID-19 infection compared with disease controls and HCs, respectively.
Conclusion: COVID-19 vaccination conferred similar protection against COVID-19 infection in terms of frequency and severity in patients with SLE to that reported by healthy individuals.
Methods: The study was based on data from 7035 fully vaccinated respondents to the online COVAD questionnaire with SLE (N = 852), rAIDs (N = 3098), or nrAIDs (N = 414), and HCs (N = 2671). BI was defined as COVID-19 infection occurring in individuals vaccinated with ≥ 2 doses (or 1 dose of J&J) ≥ 14 days after vaccination and not after 6 months since the last vaccine dose. Data were analysed using linear and logistic regression models.
Results: A total of 91/852 (10.7%) SLE patients reported at least one BI. The frequency of BIs in SLE patients was comparable to that among HCs (277/2671; p = 0.847) and patients with nrAID (39/414; p = 0.552) but higher than that among patients with other rAIDs (235/3098; p = 0.005). No demographic factors or treatments were associated with BIs in SLE patients (p ≥ 0.05 for all). Joint pain was more frequent in SLE patients than in HCs (odds ratio [OR]: 3.38; 95% confidence interval [CI]: 1.89-6.04; p < 0.001) or nrAID patients (OR: 2.44; 95% CI: 1.04-5.75; p = 0.041). Patient with SLE did not report a higher frequency of hospitalisation or need for advanced treatment for COVID-19 infection compared with disease controls and HCs, respectively.
Conclusion: COVID-19 vaccination conferred similar protection against COVID-19 infection in terms of frequency and severity in patients with SLE to that reported by healthy individuals.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Autoimmune disease; Breakthrough infection; COVID-19; Rheumatology; Survey; Systemic lupus erythematosus; Vaccination.
Elenco autori:
Palazzo, Leonardo; Lindblom, Julius; Kihlgren Olsson, Emelie; Nikiphorou, Elena; Wincup, Chris; Saha, Sreoshy; Sazliyana Shaharir, Syahrul; Katchamart, Wanruchada; Akarawatcharangura Goo, Phonpen; Traboco, Lisa; Chen, Yi-Ming; Lilleker, James B.; Nune, Arvind; Pauling, John D.; Agarwal, Vishwesh; Dzifa, Dey; Enrique Toro Gutiérrez, Carlos; Caballero-Uribe, Carlo V.; Chinoy, Hector; Study Group, Covad; Agarwal, Vikas; Gupta &, Latika; Parodis COVAD Study Group Bhupen Barman, Ioannis; Preet Singh, Yogesh; Ranjan, Rajiv; Jain, Avinash; Pandya, Sapan C.; Kumar Pilania, Rakesh; Sharma, Aman; M, Manesh Manoj; Gupta, Vikas; Kavadichanda, Chengappa G.; Sekhar Patro, Pradeepta; Ajmani, Sajal; Phatak, Sanat; Prosad Goswami, Rudra; Chandra Chowdhury, Abhra; Jacob Mathew, Ashish; Shenoy, Padnamabha; Asranna, Ajay; Talari Bommakanti, Keerthi; Shukla, Anuj; Pandey, Arun Kumar R.; Chandwar, Kunal; Kardes, Sinan; Üsküdar Cansu, Döndü; Kim, Minchul; Makol, Ashima; Chatterjee, Tulika; Pauling, John D.; Wincup, Chris; Cavagna, Lorenzo; Del Papa, Nicoletta; Sambataro, Gianluca; Fabiola, Atzeni; Govoni, Marcello; Parisi, Simone; Bartoloni Bocci, Elena; Domenico Sebastiani, Gian; Fusaro, Enrico; Sebastiani, Marco; Quartuccio, Luca; Franceschini, Franco; Paolo Sainaghi, Pier; Orsolini, Giovanni; De Angelis, Rossella; Giovanna Danielli, Maria; Venerito, Vincenzo; Milchert, Marcin; Traboco, Lisa S.; Anggoro Kusumo Wibowo, Suryo; Adrian Zamora Tehozol, Erick; Rojas Serrano, Jorge; García-De La Torre, Ignacio; Loarce-Martos, Jesús; Prieto-González, Sergio; Gil-Vila, Albert; Aranega Gonzalez, Raquel; Kuwana, Masataka; Yoshida, Akira; Nakashima, Ran; Sato, Shinji; Kimura, Naoki; Kaneko, Yuko; Knitza, Johannes; Tomaras, Stylianos; Aleksandrovna Gromova, Margarita; Aharonov, Or; Gheita, Tamer A.; Hmamouchi, Ihsane; Santos Hoff, Leonardo; Giannini, Margherita; Maurier, Francois; Campagne, Julien; Meyer, Alain; Nagy-Vincze, Melinda; Langguth, Daman; Limaye, Vidya; Needham, Merrilee; Srivastav, Nilesh; Hudson, Marie; Landon-Cardinal, Océane; Sazliyana Shaharir, Syahrul; Gerardo Rojas Zuleta, Wilmer; António Pereira Silva, José; Eurico Fonseca &, João; Zimba, Olena
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