Hybrid scaffolds with a 3D-printed polymer lattice core and a bioactive hydrogel shell for bone regeneration

Recent research in the field of tissue engineering is focusing on the realization of hybrid scaffolds as multi-material systems which allow to successfully combine the advantages of different biomaterials. In addition, additive manufacturing technologies are currently explored for their production, as means to control and personalize the scaffold structure. In this paper, composite scaffolds with a core–shell structure are studied, the core consisting of a rigid poly-l-lactic acid lattice realized by fused deposition modeling, and the shell consisting of a bioactive hydrogel, grafted upon the core and freeze-dried to develop porous microstructure. Different lattice structures are designed and realized as repetition of unit cells having different size and strut arrangement. Compression tests reveal the suitability of the mechanical properties of the scaffolds for bone tissue regeneration, and the possibility to modulate their stiffness and strength upon the lattice parameters. Moreover, the interconnected porous structure of the shell, assessed by morphological analysis at the microscope, may promote cell colonization and proliferation, while its composition may support osteogenic differentiation.