Synthesis, in vitro and in vivo biological evaluation of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones as new potent anticancer agents

3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones; Antiproliferative; Antitumor; Apoptosis; Synthesis; Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 9; Cell Proliferation; Chemistry Techniques, Synthetic; Down-Regulation; Drug Screening Assays, Antitumor; Enzyme Activation; G2 Phase; HeLa Cells; Humans; Indoles; Mitochondria; Structure-Activity Relationship; Pharmacology; Drug Discovery3003 Pharmaceutical Science; Organic Chemistry