In-vitro activity of cefotetan and other cephalosporins on Klebsiella and resistance to inactivating bacterial enzymes

The effect of cefotetan on different clinical isolates of Klebsiella has been compared to that of other cephalosporins. The post-antibiotic effect and the effect of pulse-dosing of cefotetan were also tested by an original method whereby the antibiotic was removed with an ion-exchange resin. Finally, the resistance of cefotetan to inactivating enzymes of bacterial origin has been compared with that of other cephalosporins.