Data di Pubblicazione:
2022
Abstract:
We have developed an efficient chemical resolution of racemic hydroxy substituted dithiaaza[
4]helicenes (DTA[4]H) 1(OH) using enantiopure acids as resolving agents. The better diastereomeric
separation was achieved on esters prepared with (1S)-()-camphanic acid. Subsequent simple
manipulations produced highly optically pure ( 99% enantiomeric excess) (P) and (M)-1(OH) in
good yields. The role of the position where the chiral auxiliary is inserted (cape- vs. bay-zone) and the
structure of the enantiopure acid used on successful resolution are discussed.
4]helicenes (DTA[4]H) 1(OH) using enantiopure acids as resolving agents. The better diastereomeric
separation was achieved on esters prepared with (1S)-()-camphanic acid. Subsequent simple
manipulations produced highly optically pure ( 99% enantiomeric excess) (P) and (M)-1(OH) in
good yields. The role of the position where the chiral auxiliary is inserted (cape- vs. bay-zone) and the
structure of the enantiopure acid used on successful resolution are discussed.
Tipologia CRIS:
1.1 Articolo in rivista
Elenco autori:
Lupi, Michela; Onori, Martina; Menichetti, Stefano; Abbate, Sergio; Longhi, Giovanna; Viglianisi, Caterina
Link alla scheda completa:
Link al Full Text:
Pubblicato in: