Skip to Main Content (Press Enter)

Logo UNIBS
  • ×
  • Home
  • People
  • Organizations
  • Expertise & Skills
  • Outputs
  • Jobs
  • Degrees
  • Courses
  • Third Mission

Expertise & Skills
Logo UNIBS

|

Expertise & Skills

unibs.it
  • ×
  • Home
  • People
  • Organizations
  • Expertise & Skills
  • Outputs
  • Jobs
  • Degrees
  • Courses
  • Third Mission
  1. Outputs

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

Academic Article
Publication Date:
2017
Abstract:
We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05-21.6; P=1 × 10-4) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P=8.4 × 10-7). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08-1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.
CRIS type:
1.1 Articolo in rivista
List of contributors:
Mclaughlin, R. L.; Schijven, D.; Van Rheenen, W.; Van Eijk, K. R.; O'Brien, M.; Kahn, R. S.; Ophoff, R. A.; Goris, A.; Bradley, D. G.; Al-Chalabi, A.; Van Den Berg, L. H.; Luykx, J. J.; Hardiman, O.; Veldink, J. H.; Shatunov, A.; Dekker, A. M.; Diekstra, F. P.; Pulit, S. L.; Van Der Spek, R. A. A.; Van Doormaal, P. T. C.; Sproviero, W.; Jones, A. R.; Nicholson, G. A.; Rowe, D. B.; Pamphlett, R.; Kiernan, M. C.; Bauer, D.; Kahlke, T.; Williams, K.; Eftimov, F.; Fogh, I.; Ticozzi, N.; Lin, K.; Millecamps, S.; Salachas, F.; Meininger, V.; Carvalho, M. D.; Pinto, S.; Mora, J. S.; Rojas-Garcya, R.; Polak, M.; Chandran, S.; Colville, S.; Swingler, R.; Morrison, K. E.; Shaw, P. J.; Hardy, J.; Orrell, R. W.; Pittman, A.; Sidle, K.; Fratta, P.; Malaspina, A.; Petri, S.; Abdulla, S.; Drepper, C.; Sendtner, M.; Meyer, T.; Wiedau-Pazos, M.; Lomen-Hoerth, C.; Deerlin, V. M. V.; Trojanowski, J. Q.; Elman, L.; Mccluskey, L.; Basak, N.; Meitinger, T.; Lichtner, P.; Blagojevic-Radivojkov, M.; Andres, C. R.; Maurel, C.; Bensimon, G.; Landwehrmeyer, B.; Brice, A.; Payan, C. A. M.; Saker-Delye, S.; Durr, A.; Wood, N.; Tittmann, L.; Lieb, W.; Franke, A.; Rietschel, M.; Cichon, S.; Nothen, M. M.; Amouyel, P.; Tzourio, C.; Dartigues, J. -F.; Uitterlinden, A. G.; Rivadeneira, F.; Estrada, K.; Hofman, A.; Curtis, C.; Derkooi, A. J. V.; De Visser, M.; Weber, M.; Shaw, C. E.; Smith, B. N.; Pansarasa, O.; Cereda, C.; Bo, R. D.; Comi, G. P.; D'Alfonso, S.; Bertolin, C.; Soraru, G.; Mazzini, L.; Pensato, V.; Gellera, C.; Tiloca, C.; Ratti, A.; Calvo, A.; Moglia, C.; Brunetti, M.; Arcuti, S.; Capozzo, R.; Zecca, C.; Lunetta, C.; Penco, S.; Riva, N.; Padovani, A.; Filosto, M.; Blair, I.; Nigel Leigh, P.; Casale, F.; Chio, A.; Beghi, E.; Pupillo, E.; Tortelli, R.; Logroscino, G.; Powell, J.; Ludolph, A. C.; Weishaupt, J. H.; Robberecht, W.; Damme, P. V.; Brown, R. H.; Glass, J.; Landers, J. E.; Andersen, P. M.; Corcia, P.; Vourc'H, P.; Silani, V.; Es, M. A. V.; Pasterkamp, R. J.; Lewis, C. M.; Breen, G.; Ripke, S.; Neale, B. M.; Corvin, A.; Walters, J. T. R.; Farh, K. -H.; Holmans, P. A.; Lee, P.; Bulik-Sullivan, B.; Collier, D. A.; Huang, H.; Pers, T. H.; Agartz, I.; Agerbo, E.; Albus, M.; Alexander, M.; Amin, F.; Bacanu, S. A.; Begemann, M.; Belliveau, R. A.; Bene, J.; Bergen, S. E.; Bevilacqua, E.; Bigdeli, T. B.; Black, D. W.; Bruggeman, R.; Buccola, N. G.; Buckner, R. L.; Byerley, W.; Cahn, W.; Cai, G.; Campion, D.; Cantor, R. M.; Carr, V. J.; Carrera, N.; Catts, S. V.; Chambert, K. D.; Chan, R. C. K.; Chan, R. Y. L.; Chen, E. Y. H.; Cheng, W.; Cheung, E. F. C.; Chong, S. A.; Cloninger, C. R.; Cohen, D.; Cohen, N.; Cormican, P.; Craddock, N.; Crowley, J. J.; Curtis, D.; Davidson, M.; Davis, K. L.; Degenhardt, F.; Favero, J. D.; Demontis, D.; Dikeos, D.; Dinan, T.; Djurovic, S.; Donohoe, G.; Drapeau, E.; Duan, J.; Dudbridge, F.; Durmishi, N.; Eichhammer, P.; Eriksson, J.; Escott-Price, V.; Essioux, L.; Fanous, A. H.; Farrell, M. S.; Frank, J.; Franke, L.; Freedman, R.; Freimer, N. B.; Friedl, M.; Friedman, J. I.; Fromer, M.; Genovese, G.; Georgieva, L.; Giegling, I.; Giusti-Rodryguez, P.; Godard, S.; Goldstein, J. I.; Golimbet, V.; Gopal, S.; Gratten, J.; De Haan, L.; Hammer, C.; Hamshere, M. L.; Hansen, M.; Hansen, T.; Haroutunian, V.; Hartmann, A. M.; Henskens, F. A.; Herms, S.; Hirschhorn, J. N.; Hoffmann, P.; Hofman, A.; Hollegaard, M. V.; Hougaard, D. M.; Ikeda, M.; Joa, I.; Julia, A.; Kalaydjieva, L.; Karachanak-Yankova, S.; Karjalainen, J.; Kavanagh, D.; Keller, M. C.; Kennedy, J. L.; Khrunin, A.; Kim, Y.; Klovins, J.; Knowles, J. A.; Konte, B.; Kucinskas, V.; Kucinskiene, Z. A.; Kuzelova-Ptackova, H.; Kahler, A. K.; Laurent, C.; Lee, J.; Hong Lee, S.; Legge, S. E.; Lerer, B.; Li, M.; Li, T.; Liang, K. -Y.; Lieberman, J.; Limborska, S.; Loughland, C. M.; Lubinski, J.; Lonnqvist, J.; Macek, M.; Magnusson, P. K. E.; Maher, B. S.; Maier, W.; Mallet, J.; Marsal, S.; Mattheisen, M.; Mattingsdal, M.; Mccarley, R. W.; Mcdonald, C.; Mcintosh, A. M.; Meier,
Authors of the University:
FILOSTO MASSIMILIANO
PADOVANI ALESSANDRO
Handle:
https://iris.unibs.it/handle/11379/535311
Published in:
NATURE COMMUNICATIONS
Journal
  • Support
  • Privacy
  • Use of cookies
  • Legal notes

Powered by VIVO | Designed by Cineca | 26.5.0.0