The Unique Cysteine of F-ATP Synthase OSCP Subunit Participates in Modulation of the Permeability Transition Pore
Articolo
Data di Pubblicazione:
2020
Abstract:
The effect of oxidants on PTP opening has been widely reported, yet the targets are unknown. Here, Carraro et al. identify OSCP C141 of F-ATP synthase as a target of oxidants regulating the PTP. Cyclophilin D binding to OSCP has a protective effect and prevents PTP opening induced by oxidants.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
cyclophilin D; cysteine; F-ATP synthase; mitochondria; OSCP; oxidation; permeability transition pore
Elenco autori:
Carraro, M.; Jones, K.; Sartori, G.; Schiavone, M.; Antonucci, S.; Kucharczyk, R.; di Rago, J. -P.; Franchin, C.; Arrigoni, G.; Forte, M.; Bernardi, P.
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