Publication Date:
2020
Abstract:
The role of endogenous bioelectricity in morphogenesis has recently been explored through the finite volume based code BioElectric Tissue Simulation Engine. We extend this platform to electrostatic and osmotic forces
due to bioelectrical ion fluxes, causing cell cluster deformation. We further account for mechanosensitive
ion channels, which, gated by membrane tension, modulate ion fluxes and, ultimately, bioelectrical forces. We illustrate the potentialities of this combined model of actuation and sensing with reference to cancer progression, osmoregulation, symmetry breaking, and long-range signaling. This suggests control strategies for the manipulation of cell networks in vivo
due to bioelectrical ion fluxes, causing cell cluster deformation. We further account for mechanosensitive
ion channels, which, gated by membrane tension, modulate ion fluxes and, ultimately, bioelectrical forces. We illustrate the potentialities of this combined model of actuation and sensing with reference to cancer progression, osmoregulation, symmetry breaking, and long-range signaling. This suggests control strategies for the manipulation of cell networks in vivo
CRIS type:
1.1 Articolo in rivista
Keywords:
Bioelectricity, Osmotic stress, Electrostatic stress, Mechanical stress, Mechanosensitive ion channels, morphogenesis
List of contributors:
Leronni, Alessandro; Bardella, Lorenzo; Dorfmann, Luis; Pietak, Alexis; Levin, Michael
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