Data di Pubblicazione:
2004
Abstract:
Studies suggest that anti-52 kDa Ro antibodies are more sensitive and specific than anti-60 kDa Ro antibodies for neonatal lupus. However, these studies mainly used immunoblot or ELISA using recombinant protein, which have poor sensitivity for anti-60 kDa Ro antibodies. In addition, the control patients were not disease matched. We reassessed the sensitivity and specificity of anti-52 kDa Ro, anti-60 kDa Ro, and anti-La, addressing these limitations.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Antibodies, Antinuclear; Autoantibodies; Biomarkers; Child, Preschool; Cohort Studies; Disease Progression; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Logistic Models; Lupus Erythematosus, Systemic; Male; Multivariate Analysis; Reference Values; Sensitivity and Specificity; Severity of Illness Index
Elenco autori:
Gordon, Patrick; Khamashta, Munther A; Rosenthal, Eric; Simpson, John M; Sharland, Gurleen; Brucato, Antonio; Franceschini, Franco; De Bosschere, Katrien; Meheus, Lydie; Meroni, Pier Luigi; Hughes, Graham R V; Buyon, Jill
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