Clinical outcomes in octogenarians treated with docetaxel as first-line chemotherapy for castration-resistant prostate cancer
Articolo
Data di Pubblicazione:
2016
Abstract:
AIM:
To assess clinical outcomes in octogenarians treated with docetaxel (DOC) for metastatic castration-resistant prostate cancer.
PATIENTS & METHODS:
The multicenter retrospective study was based on a review of the pre- and post-DOC clinical history, DOC treatment and outcomes.
RESULTS:
We reviewed the records of 123 patients (median age: 82 years) who received DOC every 3 weeks or weekly, without significant grade 3-4 toxicities. Median progression-free survival was 7 months; median overall survival from the start of DOC was 20 months, but post-progression treatments significantly prolonged overall survival.
CONCLUSION:
The findings of this study suggest that toxicity is acceptable, survival is independent of patient's age and survival can be significantly prolonged by the use of new agents.
To assess clinical outcomes in octogenarians treated with docetaxel (DOC) for metastatic castration-resistant prostate cancer.
PATIENTS & METHODS:
The multicenter retrospective study was based on a review of the pre- and post-DOC clinical history, DOC treatment and outcomes.
RESULTS:
We reviewed the records of 123 patients (median age: 82 years) who received DOC every 3 weeks or weekly, without significant grade 3-4 toxicities. Median progression-free survival was 7 months; median overall survival from the start of DOC was 20 months, but post-progression treatments significantly prolonged overall survival.
CONCLUSION:
The findings of this study suggest that toxicity is acceptable, survival is independent of patient's age and survival can be significantly prolonged by the use of new agents.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
castration-resistant prostate cancer; docetaxel; elderly; geriatric assessment; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Humans; Male; Proportional Hazards Models; Prostatic Neoplasms, Castration-Resistant; Retreatment; Retrospective Studies; Taxoids; Treatment Outcome; Oncology; Cancer Research
Elenco autori:
Veccia, Antonello; Caffo, Orazio; De Giorgi, Ugo; Di Lorenzo, Giuseppe; Ortega, Cinzia; Scognamiglio, Florinda; Aieta, Michele; Facchini, Gaetano; Mansueto, Giovanni; Mattioli, Rodolfo; Procopio, Giuseppe; Zagonel, Vittorina; D'Angelo, Alessandro; Spizzo, Gilbert; Bortolus, Roberto; Donini, Maddalena; Lo Re, Giovanni; Massari, Francesco; Vicario, Giovanni; Zucali, Paolo A; Alesini, Daniele; Bonetti, Andrea; Mucciarini, Claudia; Nicodemo, Maurizio; Berruti, Alfredo; Fratino, Lucia; Lodde, Michele; Messina, Caterina; Perin, Alessandra; Santini, Daniele; Sava, Teodoro; Tucci, Marcello; Basso, Umberto; Maines, Francesca; Burgio, Luca S; Galligioni, Enzo
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