In vitro and in vivo single-agent efficacy of checkpoint kinase inhibition in acute lymphoblastic leukemia

Acute lymphoblastic leukemia; Checkpoint kinase; DNA damage; Drug-sensitivity; New targets; Animals; Apoptosis; Benzodiazepinones; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Survival; Checkpoint Kinase 1; Dose-Response Relationship, Drug; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Humans; Leukemia, Experimental; Mice, Inbred C57BL; Microscopy, Fluorescence; Neoplastic Stem Cells; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Protein Kinases; Pyrazoles; Survival Analysis; Hematology; Oncology; Cancer Research; Molecular Biology