Modification of albumins by grafting poly(amido amine) chains

Bovine serum albumin and human serum albumin have been modified by grafting poly(amido amine) chains via a hydrogen-transfer addition reaction involving the available amino groups of the protein, in which the aminic character of the latter is preserved. The chemical processes involved are probably of general application for grafting multifunctional polymeric chains on to proteins under very mild, non-denaturing conditions.