Cervical carcinomas overexpress human trophoblast cell-surface marker (Trop-2) and are highly sensitive to immunotherapy with hRS7, a humanized monoclonal anti-Trop-2 antibody
Articolo
Data di Pubblicazione:
2012
Abstract:
We evaluated the expression of human trophoblast cell-surface marker (Trop-2) and the potential of hRS7, a humanized monoclonal anti-Trop-2 antibody, against treatment-refractory cervical cancer.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Adenocarcinoma; Adult; Antibodies, Monoclonal; Antigens, Neoplasm; Carcinoma, Squamous Cell; Cell Adhesion Molecules; Cell Line, Tumor; Complement System Proteins; Drug Resistance, Neoplasm; Drug Synergism; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Immunoglobulin G; Interleukin-2; Killer Cells, Natural; Real-Time Polymerase Chain Reaction; Tumor Markers, Biological; Uterine Cervical Neoplasms
Elenco autori:
Varughese, Joyce; Cocco, Emiliano; Bellone, Stefania; Ratner, Elena; Silasi, Dan Arin; Azodi, Masoud; Schwartz, Peter E; Rutherford, Thomas J; Buza, Natalia; Pecorelli, Sergio; Santin, Alessandro D.
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