Data di Pubblicazione:
2014
Abstract:
Candidate gene and genome-wide association studies (GWAS) have identified 11 independent susceptibility loci associated with bladder cancer risk. To discover additional risk variants, we conducted a new GWAS of 2422 bladder cancer cases and 5751 controls, followed by a meta-analysis with two independently published bladder cancer GWAS, resulting in a combined analysis of 6911 cases and 11 814 controls of European descent. TaqMan genotyping of 13 promising single nucleotide polymorphisms with P < 1 × 10-5 was pursued in a follow-up set of 801 cases and 1307 controls. Two new loci achieved genome-wide statistical significance: rs10936599 on 3q26.2 (P = 4.53 × 10-9) and rs907611 on 11p15.5 (P = 4.11 × 10-8). Two notable loci were also identified that approached genome-wide statistical significance: rs6104690 on 20p12.2 (P = 7.13 × 10-7) and rs4510656 on 6p22.3 (P = 6.98 × 10-7); these require further studies for confirmation. In conclusion, our study has identified new susceptibility alleles for bladder cancer risk that require fine-mapping and laboratory investigation, which could further understanding into the biological underpinnings of bladder carcinogenesis.
Tipologia CRIS:
1.1 Articolo in rivista
Elenco autori:
Figueroa, Jd; Ye, Y; Siddiq, A; Garcia Closas, M; Chatterjee, N; Prokunina Olsson, L; Cortessis, Vk; Kooperberg, C; Cussenot, O; Benhamou, S; Prescott, J; Porru, Stefano; Dinney, Cp; Malats, N; Baris, D; Purdue, M; Jacobs, Ej; Albanes, D; Wang, Z; Deng, X; Chung, Cc; Tang, W; Bas Bueno de Mesquita, H; Trichopoulos, D; Ljungberg, B; Clavel Chapelon, F; Weiderpass, E; Krogh, V; Dorronsoro, M; Travis, R; Tjønneland, A; Brenan, P; Chang Claude, J; Riboli, E; Conti, D; Gago Dominguez, M; Stern, Mc; Pike, Mc; Van Den Berg, D; Yuan, Jm; Hohensee, C; Rodabough, R; Cancel Tassin, G; Roupret, M; Comperat, E; Chen, C; De Vivo, I; Giovannucci, E; Hunter, Dj; Kraft, P; Lindstrom, S; Carta, Angela; Pavanello, S; Arici, Cecilia; Mastrangelo, G; Kamat, Am; Lerner, Sp; Barton Grossman, H; Lin, J; Gu, J; Pu, X; Hutchinson, A; Burdette, L; Wheeler, W; Kogevinas, M; Tardón, A; Serra, C; Carrato, A; García Closas, R; Lloreta, J; Schwenn, M; Karagas, Mr; Johnson, A; Schned, A; Armenti, Kr; Hosain, Gm; Andriole G., Jr; Grubb R., 3rd; Black, A; Ryan Diver, W; Gapstur, Sm; Weinstein, Sj; Virtamo, J; Haiman, Ca; Landi, Mt; Caporaso, N; Fraumeni JF, Jr; Vineis, P; Wu, X; Silverman, Dt; Chanock, S; Rothman, N.
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