Two Sequential Tc-99m ECD SPECT Studies in a Case of Sporadic Creutzfeldt–Jakob Disease Confirmed at Autopsy
Articolo
Data di Pubblicazione:
2011
Abstract:
Background: Creutzfeldt–Jakob disease (CJD) is a subacute spongiform encephalopathy characterized by rapidly progressive dementia, hard to diagnose during life.
Materials and Methods: We present a case of a patient with pathologically confirmed sporadic form of CJD in whom initial diagnostic tests were negative. Two sequential brain single-photon emission computed tomography with Tc-99m ethyl-cysteinate dimer were performed, the first one was performed few days after the admission into hospital and the second, 1 month later.
Results: Both studies revealed a decrease in regional cerebral blood flow indicative of neuronal dysfunction, more pronounced in the second study.
Conclusion: Current radionuclide scintigraphy can be an useful tool for the investigation of CJD.
Materials and Methods: We present a case of a patient with pathologically confirmed sporadic form of CJD in whom initial diagnostic tests were negative. Two sequential brain single-photon emission computed tomography with Tc-99m ethyl-cysteinate dimer were performed, the first one was performed few days after the admission into hospital and the second, 1 month later.
Results: Both studies revealed a decrease in regional cerebral blood flow indicative of neuronal dysfunction, more pronounced in the second study.
Conclusion: Current radionuclide scintigraphy can be an useful tool for the investigation of CJD.
Tipologia CRIS:
1.1 Articolo in rivista
Elenco autori:
Barbara, Paghera; Federico, Caobelli; Lutfun, Nisa; Erinda, Puta; Borroni, Barbara; Enrico, Premi; Padovani, Alessandro; Giubbini, Raffaele
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