Data di Pubblicazione:
2025
Abstract:
Background and Increasing evidence suggests that COVID-19 survivors experience long-term cardiovascular complications possibly through Aims development of vascular damage. The study aimed to investigate whether accelerated vascular ageing occurs after COVID-19 infection, and if so, identify its determinants. Methods This prospective, multicentric, cohort study, included 34 centres in 16 countries worldwide, in 4 groups of participants—COVID-19-negative controls (ⅰ) and three groups of individuals with recent (6 ± 3 months) exposure to SARS-CoV-2: not hospitalized (ⅱ), hospitalized in general wards (ⅲ), and hospitalized in intensive care units (ⅳ). The main outcome was carotid-femoral pulse wave velocity (PWV), an established biomarker of large artery stiffness. Results 2390 individuals (age 50 ± 15 years, 49.2% women) were recruited. After adjustment for confounders, all COVID-19-positive groups showed higher PWV (+0.41, +0.37, and +0.40 m/s for groups 2–4, P < .001, P = .001 and P = .003) vs. controls [PWV 7.53 (7.09; 7.97) m/s adjusted mean (95% CI)]. In sex-stratified analyses, PWV differences were significant in women [PWV (+0.55, +0.60, and +1.09 m/s for groups 2–4, P < .001 for all)], but not in men. Among COVID-19 positive women, persistent symptoms were associated with higher PWV, regardless of disease severity and cardiovascular confounders [adjusted PWV 7.52 (95% CI 7.09; 7.96) vs. 7.13 (95% CI 6.67; 7.59) m/s, P < .001]. A stable or improved PWV after 12 months was found in the COVID+ groups, whereas a progression was observed in the COVID− group. Conclusions COVID-19 is associated with early vascular ageing in the long term, especially in women.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Arterial stiffness; COVID-19; Long COVID; Sex differences; Vascular ageing
Elenco autori:
Bruno, Rosa Maria; Badhwar, Smriti; Abid, Leila; Agharazii, Mohsen; Anastasio, Fabio; Bellien, Jeremy; Burghuber, Otto; Faconti, Luca; Filipovsky, Jan; Ghiadoni, Lorenzo; Giannattasio, Cristina; Hametner, Bernhard; Hughes, Alun D; Jeroncic, Ana; Ikonomidis, Ignatios; Lonnebakken, Mai Tone; Maloberti, Alessandro; Mayer, Christopher C; Muiesan, Maria Lorenza; Paini, Anna; Panayiotou, Andrie; Park, Chloe; Rajkumar, Chakravarthi; Becerra, Carlos Ramos; Spronck, Bart; Terentes-Printzios, Dimitrios; Tuncok, Yesim; Weber, Thomas; Boutouyrie, Pierre; Null, Null; Almhofer, Herta; Danninga, Kathen; Algner, Margot; Wernhart, Martin; Weber, Thomas; Hametner, Bernhard; Mayer, Christopher C; Burghuber, Otto; Azizzadeh, Mohammad; Breyer, Marie-Kathrin; Bortolotto, Luiz; Vilela-Martin, Jose Fernando; Okawa, Rogério Toshiro Passos; Okawa, Jaqueline Lyrio Bermudes; Barroso, Weimar Kunz Sebba; Ciolac, Emmanuel Gomes; Do Amaral, Vanessa Teixeira; Fernandez, Bianca; Goupil, Rémi; Agharazii, Mohsen; Fortier, Catherine; Panayiotou, Andrie G; Photiou, Galatia; Filipovský, Jan; Mayer, Otto; Seidlerová, Jitka; Pazdiora, Petr; Hirmerová, Jana; Šustková, Lucie; Bílková, Simona; Gelžinský, Július; Kordíková, Veronika; Mareš, Štěpán; Cífková, Renata; Wohlfahrt, Peter; Kavalírová, Jana; Bruno, Rosa Maria; Boutouyrie, Pierre; Khettab, Hakim; Justin, Junior; Moriconi, Diego; Fabbri, Saverio; Hulot, Jean Sebastien; Fayol, Antoine; Courbebaisse, Marie; Parfait, Beatrice; Lebeaux, David; Friedlander, Gérard; Bellien, Jeremy; Joannides, Robinson; Iacob, Michele; Leroi, Anne-Marie; Benetos, Athanase; Georgiopoulos, Ioannis; Terentes-Printzios, Dimitrios; Christopoulou, Georgia; Tsioufis, Konstantinos; Gardikioti, Vasiliki; Vlachopoulos, Charalambos; Ikonomidis, Ignatios; Lambadiari, Vaia; Kountouri, Alkaternini; Katogiannis, Konstantinos; Jerončić, Ana; Podrug, Mario; Pavičić-Ivelja, Mirela; Koren, Pjero; Muiesan, Maria Lorenza; Paini, Anna; Salvetti, Massimo; Cacciatore, Marco; Pucci, Giacomo; Anastasio, Fabio; Scarnecchia, Elisa; Giannattasio, Cristina; Alessandro, Maloberti; Algeri, Michela; Moreo, Antonella; Tognola, Chiara; Grillo, Andrea; Fabris, Bruno; Bernardi, Stella; Rovina, Matteo; Di Pierro, Giuliano; Ghiadoni, Lorenzo; Armenia, Sabina; Bianchini, Elisabetta; Zanoli, Luca; Castellino, Pietro; Montineri, Arturo; Sciuto, Alice; Grassi, Davide; Badariene, Jolita; Ryliskyte, Ligita; Laucyte-Cibulskiene, Agne; Jancoriene, Ligita; Ryliskiene, Kristina; Juceviciene, Agne; Kovaite, Milda; Balkeviciene, Laura; Ramos-Becerra, Carlos G; Alanis-Sánchez, Guillermos; Martinez-Ayala, Pedro; Cardona-Muñóz, Ernesto G; Cardona-Muller, David; Lonnebakken, Mai Tone; Berge, Caroline Annette; Bohn, Lucimere; Oliveira, José; Alves, Emilia; Costa, Simao Pedro; Pereira, Telmo; Caseiro, Armando; Lira, Fábio; López, Maria Rosa Bernal; Moreno, María Isabel Ruiz; Huelgas, Ricardo Gómez; Sampalo, Almudena Lopez; Canovas, Jaime Sanz; Cancela, Victor Antonio Vargas; Palacios, Lidia Cobos; Sevilla, Juan José Mancebo; Zeka, Arzu Nazlı; Özpelit, Ebru; İncir, Canet; Barış, Mustafa M; Tunçok, Yeşim; Canturk, Ali; Cimilli, Hasan Can; Abid, Leila; Abdessalem, Salem; Charfeddine, Selma; Bahloul, Amine; Hammami, Rania; Walha, Mahdi; Hughes, Alun; Park, Chloe; Jamieson, Alexandra; Chowienczyk, Philip J; Faconti, Luca; Farukh, Bushra; Akhtar, Riaz; Shantsila, Alena; Lip, Gregory; Gurovich, Alvaro N; Gomez, Manuel; Stoner, Lee; Meyer, Michelle; Hanson, Erik; Zieff, Gabriel; Lassalle, Patricia Pagan; Bates, Lauren
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