Data di Pubblicazione:
2024
Abstract:
Background: Mortality among people with human immunodeficiency virus (HIV) declined with the introduction of combination antiretroviral therapy. We investigated trends in mortality in people with HIV from 1999 through 2020. Methods: Data were collected from the Data Collection on Adverse events of Anti-HIV Drugs (D:A:D) cohort between January 1999 through January 2015 and the International Cohort Consortium of Infectious Disease (RESPOND) from October 2017 through December 2020. Age-standardized all-cause and cause-specific mortality rates, classified using Coding Causes of Death in HIV, were calculated. Poisson models were used to assess mortality over time. Results: Among 55 716 participants followed for median 6 years (interquartile range, 3-11), 5263 died (mortality rate [MR], 13.7/1000 person-years of follow-up [PYFU]; 95% confidence interval [CI], 13.4-14.1). Changing mortality was observed: AIDS mortality was most common between 1999-2009 (n = 952; MR, 4.2/1000 PYFU; 95% CI, 4.0-4.5) and non-AIDS-defining malignancy (NADM) between 2010-2020 (n = 444; MR, 2.8/1000 PYFU; 95% CI, 2.5-3.1). In multivariable analysis, all-cause mortality declined (adjusted mortality rate ratio [aMRR], 0.97 per year; 95% CI,. 96-.98), mostly 1999-2010 (aMRR, 0.96 per year; 95% CI,. 95-.97) but was stable 2011-2020 (aMRR, 1.00 per year; 95% CI,. 96-1.05). Mortality due to all known causes except NADM also declined. Conclusions: Mortality among people with HIV in the D:A:D and/or RESPOND cohorts declined between 1999-2009 and was stable over the period 2010-2020. This decline in mortality was not fully explained by improvements in immunologic-virologic status or other risk factors.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
HIV; cohort collaboration; mortality; observational cohort; people with HIV
Elenco autori:
Tusch, Erich; Ryom, Lene; Pelchen-Matthews, Annegret; Mocroft, Amanda; Elbirt, Daniel; Oprea, Cristiana; Günthard, Huldrych F; Staehelin, Cornelia; Zangerle, Robert; Suarez, Isabelle; Vehreschild, Jörg Janne; Wit, Ferdinand; Menozzi, Marianna; D'Arminio Monforte, Antonella; Spagnuolo, Vincenzo; Pradier, Christian; Carlander, Christina; Suanzes, Paula; Wasmuth, Jan-Christian; Carr, Andrew; Petoumenos, Kathy; Borgans, Frauke; Bonnet, Fabrice; De Wit, Stephane; El-Sadr, Wafaa; Neesgaard, Bastian; Jaschinski, Nadine; Greenberg, Lauren; Hosein, Sean R; Gallant, Joel; Vannappagari, Vani; Young, Lital; Sabin, Caroline; Lundgren, Jens; Peters, Lars; Reekie, Joanne; Null, Null; El-Sadr, W; Calvo, G; Bonnet, F; Dabis, F; Kirk, O; Mocroft, A; Law, M; D'Arminio Monforte, A; Morfeldt, L; Pradier, C; Reiss, P; Weber, R; De Wit, S; Lind-Thomsen, A; Brandt, R Salbøl; Hillebreght, M; Zaheri, S; Wit, F W N M; Scherrer, A; Schöni-Affolter, F; Rickenbach, M; Tavelli, A; Fanti, I; Leleux, O; Mourali, J; Marec, F Le; Boerg, E; Thulin, E; Sundström, A; Bartsch, G; Thompsen, G; Necsoi, C; Delforge, M; Fontas, E; Caissotti, C; Dollet, K; Mateu, S; Torres, F; Petoumenos, K; Blance, A; Huang, R; Puhr, R; Laut, K Grønborg; Kristensen, D; Sabin, C A; Phillips, A N; Kamara, D A; Smith, C J; Mocroft, A; Hatleberg, C I; Lind-Thomsen, A; Brandt, R S; Raben, D; Matthews, C; Bojesen, A; Grevsen, A L; Lundgren, J D; Ryom, L; Powderly, B; Shortman, N; Moecklinghoff, C; Reilly, G; Franquet, X; Ryom, L; Mocroft, A; Kirk, O; Reiss, P; Smit, C; Ross, M; Fux, C A; Morlat, P; Fontas, E; Kamara, D A; Smith, C J; Lundgren, J D; Smith, C J; Ryom, L; Hatleberg, C I; Phillips, A N; Weber, R; Morlat, P; Pradier, C; Reiss, P; Wit, F W N M; Friis-Møller, N; Kowalska, J; Lundgren, J D; Sabin, C A; Ryom, L; Hatleberg, C I; Law, M; D'Arminio Monforte, A; Dabis, F; Bonnet, F; Reiss, P; Wit, F W N M; Smith, C J; Kamara, D A; Bohlius, J; Bower, M; Fätkenheuer, G; Grulich, A; Lundgren, J D; Sjøl, A; Meidahl, P; Iversen, J S; Reiss, Central P; Zaheri, S; Hillebregt, M; Wit, F W N M; Prins, J M; Kuijpers, T W; Scherpbier, H J; Van Der Meer, J T M; Wit, F W N M; Godfried, M H; Reiss, P; Van Der Poll, T; Nellen, F J B; Geerlings, S E; Van Vugt, M; Pajkrt, D; Bos, J C; Wiersinga, W J; Van Der Valk, M; Goorhuis, A; Hovius, J W; Van Eden, J; Henderiks, A; Van Hes, A M H; Mutschelknauss, M; Nobel, H E; Pijnappel, F J J; Jurriaans, S; Back, N K T; Zaaijer, H L; Berkhout, B; Cornelissen, M T E; Schinkel, C J; Thomas, X V; De Ruyter Ziekenhuis, Admiraal; Van Den Berge, M; Stegeman, A; Baas, S; De Looff, L Hage; Versteeg, D; Ziekenhuis, Catharina; Pronk, M J H; Ammerlaan, H S M; De Munnik, E S; Jansz, A R; Tjhie, J; Wegdam, M C A; Deiman, B; Scharnhorst, V; Van Der Plas, A; Weijsenfeld, A M; Van Der Ende, M E; De Vries-Sluijs, T E M S; Van Gorp, E C M; Schurink, C A M; Nouwen, J L; Verbon, A; Rijnders, B J A; Bax, H I; Van Der Feltz, M; Bassant, N; Van Beek, J E A; Vriesde, M; Van Zonneveld, L M; de Oude-Lubbers, A; van den Berg-Cameron, H J; Bruinsma-Broekman, F B; De Groot, J; De Man, M de Zeeuw-; Boucher, C A B; Koopmans, M P G; Van Kampen, J J A; Pas, S D; Mc–sophia, Erasmus; Driessen, G J A; Van Rossum, A M C; Van Der Knaap, L C; Visser, E; Branger, J; Rijkeboer-Mes, A; De Ven, C J H M Duijf-van; Ziekenhuis, Haga; Schippers, E F; Van Nieuwkoop, C; Van Ijperen, J M; Geilings, J; Van Der Hut, G; Franck, P F H; Van Eeden, A; Brokking, W; Groot, M; Elsenburg, L J M; Damen, M; Kwa, I S; Groeneveld, P H P; Bouwhuis, J W; Van Den Berg, J F; Van Hulzen, A G W; Van Der Bliek, G L; Bor, P C J; Bloembergen, P; Wolfhagen, M J H M; Ruijs, G J H M; Kroon, F P; De Boer, M G J; Bauer, M P; Jolink, H; Vollaard, A M; Dorama, W; Van Holten, N; Claas, E C J; Wessels, E; Den Hollander, J G; Pogany, K; Roukens, A; Kastelijns, M; Smit, J V; Smit, E; Struik-Kalkman, D; Tearno, C; Bezemer, M; Van Niekerk, T; Pontesilli, O; Lowe, S H; Lashof, A M L Oude; Posthouwer,
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