Monte Carlo dosimetry of silver-111 in simplified cell geometries in the framework of the ISOLPHARM project

The ISOLPHARM project of the INFN aims to study the properties of the 111Ag β− emitter as a promising core for novel radiopharmaceuticals. 111Ag will be produced at the SPES facility of the Legnaro National Laboratories, with high specific activity and remarkable yields, exploiting the ISOL technique. This work presents Monte Carlo dosimetry calculations at cellular level to assess the therapeutic potential of 111Ag within the ADMIRAL project. Using the formalism introduced by the MIRD, S-values are calculated for a biological cell exposed to different scenarios of activity distributions of 111Ag. The results of dosimetry calculations performed with GEANT4, MCNP6 and PHITS Monte Carlo codes are presented and discussed, showing a good mutual agreement and also with the MIRDcell values. These results will be used within the ISOLPHARM project for the planning of in-vitro experiments in 2D cell cultures and 3D tissue-mimicking scaffolds.