SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease
Articolo
Data di Pubblicazione:
2023
Abstract:
Serological analysis and infection outcomes of participants in the multi-center, prospectively enrolled OCTAVE cohort, comprising 2,686 participants with immune-suppressive diseases who recieved two COVID-19 vaccines, reveals specific clinical phenotypes that might benefit from specific COVID-19 therapeutic strategies.Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immune responses and infection outcomes were evaluated in 2,686 patients with varying immune-suppressive disease states after administration of two Coronavirus Disease 2019 (COVID-19) vaccines. Overall, 255 of 2,204 (12%) patients failed to develop anti-spike antibodies, with an additional 600 of 2,204 (27%) patients generating low levels (< 380 AU ml(-1)). Vaccine failure rates were highest in ANCA-associated vasculitis on rituximab (21/29, 72%), hemodialysis on immunosuppressive therapy (6/30, 20%) and solid organ transplant recipients (20/81, 25% and 141/458, 31%). SARS-CoV-2-specific T cell responses were detected in 513 of 580 (88%) patients, with lower T cell magnitude or proportion in hemodialysis, allogeneic hematopoietic stem cell transplantation and liver transplant recipients (versus healthy controls). Humoral responses against Omicron (BA.1) were reduced, although cross-reactive T cell responses were sustained in all participants for whom these data were available. BNT162b2 was associated with higher antibody but lower cellular responses compared to ChAdOx1 nCoV-19 vaccination. We report 474 SARS-CoV-2 infection episodes, including 48 individuals with hospitalization or death from COVID-19. Decreased magnitude of both the serological and the T cell response was associated with severe COVID-19. Overall, we identified clinical phenotypes that may benefit from targeted COVID-19 therapeutic strategies.
Tipologia CRIS:
1.1 Articolo in rivista
Elenco autori:
Barnes, Eleanor; Goodyear, Carl S.; Willicombe, Michelle; Gaskell, Charlotte; Siebert, Stefan; I de Silva, Thushan; Murray, Sam M.; Rea, Daniel; Snowden, John A.; Carroll, Miles; Pirrie, Sarah; Bowden, Sarah J.; Dunachie, Susanna J.; Richter, Alex; Lim, Zixiang; Satsangi, Jack; Cook, Gordon; Pope, Ann; Hughes, Ana; Harrison, Molly; Lim, Sean H.; Miller, Paul; Klenerman, Paul; Richter, Alex G.; Mentzer, Alex; Deeks, Alexandra; Jamsen, Anni; Brown, Anthony; Conlon, Chris; Dold, Chris; Duncan, Christopher J. A.; Skelly, Donal; Kronsteiner, Barbara; Abraham, Priyanka; Phillips, Eloise; Jeffery, Katie; Turtle, Lance; Frending, Lisa; Stafford, Lizzie; Ali, Mohammad; Rongkard, Patpong; Payne, Rebecca; Adele, Sandra; Travis, Simon; Gardiner, Siobhan; Dobson, Sue L.; Malone, Tom; Bibi, Sagida; Carroll, Miles; Faustini, Sian; Foulkes, Sarah; Frater, John; Hall, Victoria; Hopkins, Susan; Islam, Jasmin; Lambe, Teresa; Longet, Stephanie; Moore, Shona C.; Otter, Ashley; Rowland-Jones, Sarah L.; Thaventhir, James E. D.; Wootton, Daniel G.; Basu, Neil; Gilmour, Ashley; Irwin, Sophie; Meacham, Georgina; Marjot, Thomas; Dimitriadis, Stavros; Kelleher, Peter; Prendecki, Maria; Clarke, Candice; Mortimer, Paige; Mcintyre, Stacey; Selby, Rachael; Meardon, Naomi; Nguyen, Dung; Tipton, Tom; Longet, Stephanie; Laidlaw, Stephen; Orchard, Kim; Ireland, Georgina; Brown, Kevin; Amirthalingam, Gayatri; Thomas, David; Kearns, Pamela; Kirkham, Amanda; Mcinnes, Iain B.; Beesley, Richard; Churchill, Vicky; Loughton, Holly; Insch, Elspeth; Macdonald, Eilean; Middleton, Gary; Billingham, Lucinda; Lowe, Faye; Magwaro, Sophia; Al-Taei, Saly; Arnott, Maxine; Bennett, Louise; Brock, James; Keillor, Victora; Melville, Andrew; Melville, Lisa; Miller, Samantha; Najm, Aurelie; Paterson, Caron; Rodgers, Lewis; Rutherford, Matthew; Rundell, Suzann; Smith, Emily; Stewart, Lynn; Sunzini, Flavia; Tong, Andrew; Woolcock, Kieran; Basheer, Faisal; Crawley, Charles; Malladi, Ram; King, Andrew; Lockey, Sophie; Uttenthal, Ben; Koh, Mickey B. C.; Hansford, Sam; Sandhar, Gurjinder; Kesavan, Murali; Moore, Celia; Manousou, Pinelopi; Hahn, Gareth; Mullish, Benjamin; Atta, Maria; Gleeson, Sarah; Lightstone, Liz; Martin, Paul; Mcadoo, Stephen; Thomson, Tina; Avenoso, Daniele; Sanderson, Robin; Taylor, Claire; Bhandal, Khushpreet; Hull, Diana; Trivedi, Palak; Filer, Andrew; Hurst, Erin; Publicover, Amy; Scouse, Katy; Chalk, Jem; Hanke, Daniel; Hanke, Josef; Healy, Saoirse; Provine, Nicholas; Thomas, Sarah; Walker, Victoria; Win, Zay; Trown, Doreen; Faria, Patricia; Chackathayil, Julie; Hutchison, Clare; Richardson, Deborah; Null, Null; Null, Null; Null, Null
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