Polychlorinated biphenyls and thyroid hormone serum concentrations among people living in highly polluted area: a cross-sectional population-based study
Articolo
Data di Pubblicazione:
2008
Abstract:
Background: Polychlorinatedbiphenyls(PCBs)mayinteractwithseveralthyroidfunctions.Severe
environmentalpollutionbyPCBshasbeenobservedinBrescia,Italy,duetothepresenceofafactory
that producedthesecompoundsuntil1984.
Objectives: WeaimedtoinvestigatethecorrelationbetweenserumlevelsoftotalPCBsandPCB153and
thyroidhormoneserumlevelsinadultsinacross-sectionalpopulation-basedstudy.
Methods: A totalof527subjectswereenrolled;theywereface-to-faceinterviewedabouttheirhistory
of thyroiddiseaseandprovidedabloodsampleunderfastingconditions.Theserumlevelsoffreeand
totaltriiodothyronine(FT3andTT3),thyroxine(FT4andTT4)andthyroid-stimulatinghormone(TSH),
anti-thyroperoxidase(anti-TPO)andanti-thyroglobulin(anti-TGA),andlipid-adjustedtotalPCBsand
PCB 153weredetermined.
Results: There wasnostatisticallysignificantdifferenceintotalPCBandPCB153concentrationsin
subjectswithandwithoutthyroiddisease.Inverse,weak,statisticallysignificantcorrelationswere
foundbetweentotalPCBsandFT3(Spearman’s r ¼ 0.09) andbetweentotalPCBsandPCB153andTSH
(Spearman’s r ¼ 0.16and 0.12,respectively).However,multipleregressionanalysiswithFT3andTSH
serum levelsasdependentvariablesandtotalPCBsandPCB153serumlevelsaspredictors,including
age, genderandBMI,showedapositive,ratherthannegative,associationofPCBsandPCB153withFT3
and noassociationwithTSH.
Conclusions: This studydoesnotsupportthehypothesisthatrelativelyhighPCBenvironmental
exposurecandeterminesubstantialalterationsinthyroidfunctionamongadultpeople.
environmentalpollutionbyPCBshasbeenobservedinBrescia,Italy,duetothepresenceofafactory
that producedthesecompoundsuntil1984.
Objectives: WeaimedtoinvestigatethecorrelationbetweenserumlevelsoftotalPCBsandPCB153and
thyroidhormoneserumlevelsinadultsinacross-sectionalpopulation-basedstudy.
Methods: A totalof527subjectswereenrolled;theywereface-to-faceinterviewedabouttheirhistory
of thyroiddiseaseandprovidedabloodsampleunderfastingconditions.Theserumlevelsoffreeand
totaltriiodothyronine(FT3andTT3),thyroxine(FT4andTT4)andthyroid-stimulatinghormone(TSH),
anti-thyroperoxidase(anti-TPO)andanti-thyroglobulin(anti-TGA),andlipid-adjustedtotalPCBsand
PCB 153weredetermined.
Results: There wasnostatisticallysignificantdifferenceintotalPCBandPCB153concentrationsin
subjectswithandwithoutthyroiddisease.Inverse,weak,statisticallysignificantcorrelationswere
foundbetweentotalPCBsandFT3(Spearman’s r ¼ 0.09) andbetweentotalPCBsandPCB153andTSH
(Spearman’s r ¼ 0.16and 0.12,respectively).However,multipleregressionanalysiswithFT3andTSH
serum levelsasdependentvariablesandtotalPCBsandPCB153serumlevelsaspredictors,including
age, genderandBMI,showedapositive,ratherthannegative,associationofPCBsandPCB153withFT3
and noassociationwithTSH.
Conclusions: This studydoesnotsupportthehypothesisthatrelativelyhighPCBenvironmental
exposurecandeterminesubstantialalterationsinthyroidfunctionamongadultpeople.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Serum PCB concentration; lipid-adjusted PCB concentration; Thyroid Hormone; cross-sectional population study
Elenco autori:
Donato, Francesco; Zani, Claudia; Magoni, Michele; Gelatti, Umberto; Covolo, Loredana; Orizio, Grazia; Speziani, F; Indelicato, A; Scarcella, Carmelo; Bergonzi, Roberto; Apostoli, Pietro
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